Hydroxyprogesterone

Chemical name

17-Гидроксипрегн-4-ен-3,2 0-дион (and in the form of acetate or kaproata)

Gross

C21-H30-O3

Characteristics

White or white with a slightly yellowish white crystalline powder. Nerastvorim in water, soluble in alcohol, the fatty oils.

Of drugs

The drugs-progestagennoe. Associated with the receptor kletok-mishenei designed to endogenous hormone yellow Bodies (progesterone), and is similar biological effects. The move mucous membrane of the uterus phase proliferation (adjustable folliculrian hormone) in secretornuu providing optimal conditions for implantation and development of a fertilized egg. Reduces anxiety and airway muscles uterus and fallopian tubes, stimulates the end of breast cancer. After a single on / m of oil solution to the continuing 1-2 weeks.

Indications

Under yellow body : normal and threatening cancer (prevention), the need for an early intervention pregnant uterus; Amenorea and polimenorea.

Contraindications

Pregnancy (except habitual incomplete in the first half of pregnancy), holetsatical yellows (during pregnancy in history), cirrhosis, giperbilirubinemia clean, hard liver failure, neoplasms genitals and mammary glands, the propensity to tromboobrazovaniu.

Side-Effects

Nausea, vomiting, bleeding breeding and peripheral oedema, parestesia, increased body mass index, increased fatigability, tachycardia, allergic reactions (skin rash). Excessive progestagenov may cause virilizatia female foetuses (until uncertainty sex).

Patient interaction

Changes gipoglikemisiruth effects of oral anticoagulants, Corticosteroids (combine with caution). Gestagennouu activity reduces induktora mikrosomalnogo oxidation (barbiturates gidantoin, rifampicin, etc.).

Dosing and Administration

V / m. For the prevention and treatment угрожающего/начавшег��ся Abortion-0,125-0,25 g once a week, in case amenoree 0.25 g one or two reception for the treatment of dysfunctional uterine bleeding-0,0625-0,125 g per 22 day cycle.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Hydroxyprogesterone