Jeanine

Roman name

Jeanine #

The composition and the form of

1 tablet contains etinilestradiola 0.03 mg and dienoguesta 2 mg; blistere in 21 pcs. , in a cardboard unit 1, or 3 blisters.

Characteristics

Nizkodozirovanny monofazny oral contraceptive.

Of drugs

Contraceptive. Stops ovulation and increases the viscosity of cervical mucus. Normalizes the menstrual cycle, which reduces the frequency of painful menstruation, bleeding intensity and the risk of iron deficiency. Dienoguest - gestagen with antiandrogenna activity (shown in a study in patients with acne and rash), has a positive impact on the lipid composition of the blood, raising LPVP.

Pharmacokinetics

Этинилэстрадиол.Полн��стью fans of thin intestines, C_max achieved through GHG p at 118 ng / l after repeated reception. The absolute bioavailability of about 44% (effect of the first pass through the liver). Linking albuminom 98.5%, not associated with the transport of plasma proteins. Metabolised mainly by gidrauxilirovania followed with kongugirovaniem glukuronova and / or sulphuric acid (glukuronid be partially re-absorption in the gut). T_1/2 after three cycles of treatment, 15 hours Write memory (30-50%) and faeces (40%). Dienoguest.bystro and almost completely absorbed from the digestive tract, absolute bioavailability 96% C_max is about 2.5 hours Linking albuminom about 90%, not associated with specific transport protein linking sex hormones and corticosteroids, and it is not replacing testosterone and kortizol and does not affect the operations of endogenous steroids. Metabolised by gidrauxilirovania, gidrogenization, kongugirovania flavoring and with the formation of active metabolites. T_1/2 of plasma, with the repeated admission about 10 hours total Cl after three cycles of treatment is 2.8 l / h. Return with urine and faeces in the ratio 3:1.

Indications

Prevention of unwanted pregnancy (additional benefits for patients with acne and rash, seboreei, girsutizmom and androgenna alopecia).

Pregnancy and lactation

Contraindicated in pregnancy. Not recommended through breastfeeding.

Contraindications

Hypersensitivity, thrombosis (venous and arteritis), incl. in history, the preceding car (eg tranzitornaya coronary attack, stenocardia), as well as heavy or multiple risk factors of atherosclerosis; diabetes mellitus with circulatory complications severe disease and cancers (including in history), the liver, gormonozawisimae cancers of the reproductive organs or mammary glands (actual or suspected), vaginal bleeding ambiguous genesis, pregnancy (actual or suspected).

Side-Effects

From the nervous system and sensory organs : headaches, migraines, Deprescia.so part of the intestine : nausea, Rvota.so the urogenital system : change vaginal Secretii.so the Skin : Various skin reactions hloazma (especially for patients with hloazma pregnant in history). Other : bloating and pain mammary glands, the allocation of them secret, the delay fluid changing body mass index, poor portability contact lenses allergic reactions, changing face.

Specific guidance

Against the backdrop of the admission of drugs, especially in the early months, there can be a irregular bleeding (mazhushchie a frog or krovtechenia), which becomes important only after a period of adaptation (3 cycle). Stroidnye sex hormones may influence the results of the laboratory tests that reflect liver function, thyroid, napochechnikov and kidney and the level of transport proteins, the Carbohydrate exchange, coagulation and fibrinolysis.

Patient interaction

Simultaneous long reception gidantoina, barbiturates, primidona, carbamazepina and rifampitina and presumably topiramata and grizeofulvina weakening effect. Some antibiotics (such as penicillin and tetratziklin) decreasing seconds.

Overdosing

Symptoms : nausea, Rvota.lechenie : symptomatic.

Precautions

With long-term use every six months to monitor preventive Obsledovanie.jenshchina with diabetes should be carefully monitored Vracha.otsutstvie bleeding out twice or temporary admission require drug testing for graduation беременности.Развити�� symptoms of venous or arterial thrombosis (unilateral pain and / or swelling in the leg, sudden severe pain in the chest with irradiaciei in the left arm or not, dizziness, severe cough; unusual, severe, prolonged headache; increased frequency and severity of migraines, sudden partial or total loss of sight, diplopia, neclenorazdelnaya speech or speakers, dizziness, collapse with the expansion pripadkom or without him; weakness or a large sudden loss of sensation on one side or in one part of the body, propulsion violations "severe" stomach) requires an admission of drug and consultation Vraca.pri gipertriglitzeridiemii, incl. in the family history increases the risk of Pankreatita.pri development arm, clinically meaningful arterial hypertension, of the liver, retidiviruta holetsaticescoy jaundice, discontinue use of the drug.

Dosing and Administration

Inside, with a small amount of water, about the same time of day, and 1 tablet a day, starting with the first round of the day (which is allowed to receive from the cycle, but in this case it is recommended to use an additional barrier method of contraception for the first 7 days) on the scheme specified on the package. After 21 days was adjourned for seven days, during which there has been bleeding the (usually arises at 2-3-i day after receiving the last jar, and can last up to the start of the reception preparation of a new package).

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