Klimen

Roman name

Climen

The composition and the form of

1 jar white contains seconds valerate 2 mg and 1 jar pink-jet valerate 2 mg and ciproteron acetate 1 mg; blistere in with the scale of calendar 1921 pcs. (11 tablets white and 10 tablets pink), in a carton one blister.

Indications

Climacteric (hormone replacement therapy) : psychovegetative disturbances inwalucia symptoms of the skin, dry mucous membranes reproductive organs androgenization phenomenon; Postmenopauznogo prevention of osteoporosis; Estrogennaya insufficiency (ovarioektomia about benign neoplasms), menstrual irregularities-primary and secondary amenorea et al.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Pregnancy, breast-feeding expressed violations of the liver, jaundice or permanent skin during pregnancy disorder (formerly); Liver tumors (including in history); Ovarian tumors, breast, uterus; Endometriosis (appearance in the various organs of tissue, similar structure to the inner liner uterus and are cyclical changes in the menstrualnomu cycle); embolic processes (the road receptacles); severe diabetes with circulatory complications; sickle cell disease (Inherited Hemolytic anemia, increased erythrocyte breakdown in the blood); Violations of lipid (fat) exchange; herpes pregnant (viral infection, vsapaniem marked on the skin and / or mucous membranes shells grouped bubbles) in history; otoscleros (progressive hearing impairment and noise in the ears), with the deterioration in pregnancy.

Specific guidance

Changes biochemical indicators of liver, thyroid, napochechnikov, kidneys, the transport proteins of plasma (incl. кортикостероид-связы��ающего OKT3, �ипидно/липопротеинов ых fractions of hydrocarbons exchange, coagulation and fibrinolysis).

Patient interaction

PP, inducyrute liver enzymes (anti, anti, and other drugs), increased metabolism of steroid hormones and reduce the clinical effectiveness. Antibiotics (penicillin, tetratziklin) lower effective concentration. PP affected conjugation (including paracetamol), increased bioavailability seconds through competitive inhibition of conjugation in the intake in the gut. Together appointment may need to be adjusted doses gipoglikemicakih drugs. Ethanol increases seconds in the blood.

Overdosing

The increasing incidence described side effects.

Precautions

Before treatment required for general and gynaecological examinations, incl. study mammary glands, cytological examination cervical mucus, with the exception of pregnancy, diseases of blood clotting. It should be borne in mind that Klimen ® should not be used as a method of contraception.

Dosing and Administration

The inside is not liquid, squeezed small amount of fluid about the same time, one tablet a day, from the 5th day cycle. After receiving it from one calendar packages are day break, during which the 2-4 day after receiving the last Bean begins menstrualnopodobnoe bleeding. If a doctor does not prescribe a different medication, after the seven-day suspension to start the preparation of the next calendar packaging. In the absence of seven break bleeding, treatment continues only after excluding pregnancy.

Storage conditions

B. List at room temperature.

Shelf life

5 years

The registration

013533/01

Of drugs

Combined product containing estrogen (female sex hormones), valert seconds and antiandrogen (a substance that has the opposite effects of male sex hormones), ciproteron acetate with gestagennami (such action hormones yellow body cancer) properties. Is to hormone replacement therapy, vospolnatm in women deficit sex hormones. It reduces or eliminates the symptoms of climacteric has a preventive effect on the development of osteoporosis (eating disorders of bone tissue, with the increase in the bone associated with changing hormone background), and cardiovascular diseases.

Indications for use

Substitution treatment of climacteric manifested psichowegetativei violations atroficescimi processes in the skin and the sand mucous membranes urinary tract, androgenization phenomena; Prevention of osteoporosis and cardiovascular disease in postmenopause; Estrogennaya insufficiency after ovariektromii about oncological diseases; Treating disorders menstrual cycle (including primary and secondary amenorea lack of menstruation).

Side-Effects

The sense of tension in the mammary glands, discomfort in epigastria (the abdomen, located directly beneath mud arches rib and the sternum), the change in mass body, nausea, change in libido (sexual desire). Rarely, headache, lower mood. Perhaps a majuth menstrualnopodobnykh krovotcheni.

Form of

Bonbons packed calendar scale to 21 stuke (11 tablets white containing 2 mg estradiol valerate and 10 tablets pink containing 2 mg seconds valerate and 1 mg ciproteron acetate).

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Klimen