Klimodien

Roman name

Climodien #

The composition and the form of

1 tablet coated liner contains seconds valerate 2 mg and dienoguesta 2 mg; in a contour acheikova packing 28 pcs. , in a cardboard bundle one package.

Of drugs

Antiklimaktericescoe, mode, gestagennoe, antiandrogennoe. Whereas estrogen deficit, eliminates psihoemozionale week and changing disorders, involution of the skin and mucous membranes (especially urogenital system), prevents hyperplasia of endometrium and contributes to the bone reduced and, in many cases, followed by the termination of bleeding. Provides prototec effect on the cardiovascular system, lowers the level of cholesterol and reasonable increases-LPVP has a direct effect vazotroponam (elevates the vazodilatace markers in the urine). Prevents loss of bone mass, improves the subjective quality of sleep in women suffering from insomnia.

Pharmacokinetics

Valerat.pri seconds removals (rapid and full), and the first passage through the liver split in estradiol (bioavailability 3-6%) and valerianovu acid C_max jet won at 2-10 h, with the ratio estrona / 4:1 seconds. Associated with albuminom and globulinom linking sex hormones, equilibrium concentration, between 40 and 90 ng / O Estradiol metabolised mainly in the liver, as well as in the gut, kidneys, skeletal muscles and organah-misheniah education estrona, estriola, kateholestrogenov and kongugatov with glukuronova and sulphuric acid. Concentration estrona nearly seven-fold, and estrona sulfate-150 times higher concentrations seconds (levels seconds estrona and returned to baseline values within 2-3 days after admission). Neither is kishechno-pechenocna recycling, presented with urine in the form of метаболитов.Диеногес��.Быстро and almost completely absorbed from the digestive tract, the absolute bioavailability of about 90%, C_max (54 ng / l) is about 1 h. Associated with albuminom about 90%. Metabolised by gidrauxilirovania, gidrogenization, kongugirovania flavoring and with the formation of active metabolites. T_1/2 final phase eliminicaii of plasma about 11 hours total Cl-3.2 l / h. Write mainly with urine in the form of metabolites.

Indications

Substitution hormonal therapy symptoms of estrogen deficiency for women in menopause (no earlier than one year after its occurrence).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, vaginal bleeding unclear etiology, breast cancer (fixed or foreseen), gormonozawisimae Pre disease, or malignant tumours (actual or suspected), the liver tumors (benign or malignant), incl. in the disease, severe liver disease, thrombosis deep vein under deteriorate tromboembolia or reliable information on the conditions in the past; heavy gipertriglitzeridemia, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : headaches, migraines, dizziness, increased fatigability, reducing mood, rarely feeling anxious Bessonnica.so the circulatory system and blood (blood, gemostaz) : AD improving or worsening of arterial hypertension, rarely throm, pulmonary veins, the pain's veins, arterial gipotenzia, Anemia.so part of the intestine : nausea, vomiting, pain in the abdomen, bloating, neuralgia, raising gammaglutamintransferzy rarely-lock, Gastrit.so the urogenital system : more 1% leap bleeding, thickening endometrium, vulvowaginit; at 1% change in vaginal secretions, fibrosno-kistosnye of dairy Jelez.so the Skin : rarely increased 16469 sweating, exantema, eczema, dermatitis akneformny, Alopecia.prochie : changing body mass index, tides heat, bloating and pain mammary glands, molocnica; rarely swelling legs, muscle stiffness, a change drive, allergic reactions, the change in the level of lipids in the blood, raising the level of glucose in the blood.

Specific guidance

Sexual societies hormones can influence the results of the laboratory tests that reflect liver function, thyroid, napochechnikov and kidney as well as on the transport proteins, the Carbohydrate exchange, coagulation and fibrinolysis.

Patient interaction

Simultaneous long reception gidantoina, barbiturates, primidona, carbamazepina and rifampitina and presumably topiramata and grizeofulvina weakening effect. Some antibiotics (such as penicillin and tetratziklin) decreasing seconds, alcohol increases. Paracetamol and other substances are conjugation increase the bioavailability seconds.

Precautions

Before receiving medication to a general and gynaecological examination, and that violations of the withdrawal Krovi.vo treatment should be held periodically check обследования.Пациент�� with hyperbilirubinemia, moderately high triglycerides in the blood and diabetes should be under special Nabludeniem.vperve having migrenepodobnaya or unusually severe and recurring headaches, the development of resistant clinically meaningful hypertension, retidiviruta holetsaticescoy jaundice or cholestatic itching increase mioma uterus, endometriosis patients require the drug. Frequent or persistirute pathological uterine bleeding during a drug warrant for the study endometrium. Women tend to hloazme should avoid prolonged stay in the sun and UV Oblucenia.ne intended to apply as a means of contraception, and to restore fertility.

Dosing and Administration

Inside, with liquid squeezed small amounts of fluid around the same time of day, for one tablet a day.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Klimodien