Klostilbegit

Roman name

Clostilbegyt

Pharmacokinetics

Well drawn from the blood. Metabolised in the liver. T_1/2 - 5-7 days. 37-51% klomifena out with faeces, a small number (including in the form of metabolites) appears in the urine.

Farmakodinamika

With low content in the body of endogenous estrogen has been moderate estrogenny effect.

Indications

Enlisting the moment when anovulatornah cycles of treatment decreases with inadequate functions hypothalamus, secondary amenorea different etiology, oligomenorea, dysfunctional uterine bleeding, galactorea (with the exception of tumor genesis) syndrome Stein - Leventhal, Chiari syndrome - Frommel, oligospermia.

Pregnancy and lactation

Contraindicated in pregnancy.

Contraindications

Гиперчувствительност ь to components of the drug, a violation of the liver, ovarian cyst, malignant neoplasms genitals, and the primary hypothyreosis glands, uterine bleeding unknown etiology, pregnancy (including suspected it).

Patient interaction

The medication with drug Klostilbegit yet to materialize.

Precautions

Before and during the course of treatment (continuing) should carry out a thorough survey of cancer. Treatment works in the normal or low levels of excretion gonadotropinov, unchanged (palpation), the status of the ovaries, as well as skorrigirovanna the thyroid gland and napochechnikov. In the absence owulyatsi prior to the start of treatment to other causes of infertility, or the appropriate treatment. When the ovaries or kistoederal transformation treatment to suspend normalization of their size. Continue therapy with the use of minimal doses or shorten the period of treatment. Из-за трудности определения времени овуляции и недостаточности функции желтого тела, после лечения рекомендуется профилактическое назначение прогестерона. The control function of the liver. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, with regular treatment menstruationh beginning at 5 day cycle. The first course is 50 mg / day for 5 days (owulyatsia usually occurs between 11 and 15 days cycle). In the absence of ovulation a second course is 100 mg / day for five days, if necessary, the third. If there is no effect after months suspension is a further three-month course. The maximum dose for one course is not more than 750 mg. In amenoree arising after the contraceptive drugs-50 mg / day for 5 days. In oligospermii -- 50 mg 1-2 times a day for six weeks (under systematic monitoring scarcity).

Storage conditions

List B. The temperature 15-25 ° C

Shelf life

5 years

The registration

014432/01-2002

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