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Livial

See also Tibolone

Roman name

Livial

The composition and the form of

1 tablet contains tibolona 2.5 mg; blistere in 28 pcs. , in a cardboard bundle one blister.

Of drugs

The drug for the treatment of menopausal syndrome. 4-3 work гипоталамо-гипофизар��ой of menopausal that achieved by oestrogen (female sex hormone), progestagennah (such action hormones yellow body) and the weak androgennah (such action male sex hormones) properties of the preparation. The women in postmenopause (in the post-period) livial in daily dose of 2.5 mg suppresses the secretion (a) gonadotropinov (pituitary hormones that stimulate the activity of sexual glands), discourages proliferatiou endometrium. (increase in the number of cells internal layer cancer as a result of their reproduction), prevents the loss of bone mass in postmenopauzne period reduces vazomotornah disorders (tides, old), has a positive effect on libido (sexual desire) and the mood, as well as a stimulating effect on the mucous membrane of the vagina. The fertile women (women of child-bearing age) product ingibiruet ovulation (suppresses withdrawal mature egg from the ovary).

Pharmacokinetics

Once inside quickly and completely absorbed from the digestive tract. Biotransformiroetsa education three pharmacologically active metabolites : 3-alfa-on-tibolon and 3-beta-on-tibolon have mostly estrogenna activity delta-4-izomer has progestagenna and weak androgenna activity. C_max 3-alfa-on- and 3-beta-on-metabolitov achieved through half hour T_1/2 is about 160161 not accumulate. Write mainly in the form of metabolites, mostly in faeces, a small number of them from urine.

Indications

Symptoms natural or artificial menopause; Prevention of osteoporosis due to the lack of estrogen.

Pregnancy and lactation

Contraindicated in pregnancy.

Contraindications

Pregnancy, diagnostirovannaya hormonal cancer or suspected it, serdechnososudistye or cerebrovascular disorders (human cerebral circulation), including history (history), uterine bleeding unknown etiology (cause).

Side-Effects

Livial is usually well tolerated and the frequency of side effects developing during his reception low. Sometimes, changes in body mass index, dizziness, seborainey dermatitis, Vaginal bleeding, headache, stomach disorder, the evolution of the liver, excess owolosenie.

Specific guidance

If the reason for not гормонозаместительно й estrogenami therapy is Vaginal bleeding before treatment Livialom should ascertain its cause.

Patient interaction

Do the anti increases the need for the gipoglikemicakih (reduces tolerance to glukoze). Declining activity while application rifampitina, carbamazepina.

Overdosing

Episodes of acute poisoning Livialom expressed weakly, usually with admission several tablets intoxication is not. Possible violations of the digestive tract. Specific treatment is not required.

Precautions

In Liviala admission to the annual medical examination.

Dosing and Administration

Admission liviala should begin after one year after the last natural menstruation. If you start receiving the drug before, there may be occasional krovanistye allocation. Livial take 1 tablet (2.5 mg) per day, preferably at the same time. Better comes in the next few weeks, but best results are for continuing treatment for at least three months. The recommended dose of the drug admission may last for a longer time. Beginning to take pills from the top obwedennogo a framed stimulants, the first host to, which marked the day of the week. The pills are taken for one day out of the package in the direction of the arrow until the whole package.

Storage conditions

List B. In a dry, the dark place at a temperature of 2-25 ° C

Shelf life

2

The registration

013686/01-2002

Indications for use

Symptoms natural or surgical menopause (cessation of menstruation as a result of natural causes or hururgicaki interference).

Form of

Tablets 2.5 mg per pack to 28 pieces.

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