Mifepristone

Chemical name

(11-бета,17бета)-11-[4-(Диме тиламино)фенил]-17-гидр окси-17-(1-пропинил)эстр а-4,9-диен-3-он

Gross

C29-H35-N-O2

Characteristics

Crystalline powder from the yellow to greenish white to yellow to greenish-brown color.

Of drugs

The drugs-antiprogestagennoe. Lock of the progesterone level loads. Rapidly absorbed, which is highly associated with plasma proteins. T_1/2-1 p.m.

Indications

Interruption of uterine pregnancy in the early stages (up to 42 days amenorrhea).

Pregnancy and lactation

Contraindicated in pregnancy : not confirmed clinical research for more than 42 days after the cessation of menstruation, resulting in the face of intrauterine contraception, or after the hormonal contraception, suspected ectopic pregnancy. Breast-feeding should be discontinued 14 days after taking the medication.

Contraindications

Hypersensitivity, pregnancy, Uncertified clinical research or exceeding date 42 days after the cessation of menstruation, or having in the face of intrauterine contraception, or after the hormonal contraception, the suspected ectopic pregnancy, a scar on the uterus, cervix mioma, napochechnikovaya and / or kidney and / or liver failure, inflammatory diseases of the vagina, long-term care insurance korticosteroidami, violation of hemostasis, anaemia, age over 35 years, combined with smoking.

Side-Effects

Breeding bleeding, pain at the bottom of the stomach, inflammation of the uterus and appendages, infection uterus and urinary tract, a sense of discomfort in the abdomen, weakness, headache, dizziness, nausea, vomiting, diarrhoea, hyperthermia.

Specific guidance

It should inform patientku that in the event of failure to drug to terminate pregnancies other way (perhaps a congenital malformations fruit). The product requires general activities related to abortion, including the Rh alloimmunization.

Patient interaction

Should be avoided with NPVS (including aspirin), as a result of possible changes in effectiveness.

Overdosing

Symptoms : acute napochechnikovaya failure.

Precautions

Application for a hospital (medical facility belonging to the public health system). Be wary of the patients with bronchial asthma and COPD chronic respiratory diseases, cardiovascular diseases and exposure to them. The cross breeding bleeding may require immediate surgery (curettage). There is a need for caution in the acceptance of synthetic GHGs.

Dosing and Administration

Inside, 600 mg once. After 8-14 days to clinical examination, ultrasound, Betahg level in the blood. If there is no effect on the 14th day (incomplete abortions, the continued pregnancy) are wakuumaspiratiou followed Histologic study aspirata.

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