Norethisterone

Chemical name

(17 альфа)-17-Гидрокси-19-но��прегн-4-ен-20-ин-3-он (and in the form of acetate or enanthate)

Gross

C29-H26-O2

Of drugs

The drugs-gestagennoe. Stops proliferativuyu activity giperplazirovannom endometrii contributes to the secretion of transformation of the reaction deciduhalna stroma and atroficski changes anal glands and stroma. Oppressing the gonadotroponah hormones Gipofizom.horosho absorbed by ingestion. Time to C_max is about 2 hours In the liver, with the participation of enzymes mikrosomalnogo oxidation is biotransformation. T_1/2 - 3-10 hours Excreted in the urine (70% imposed dose), and gastrointestinal.

Indications

Pre syndrome, mastodinia, disorders menstrual cycle associated with the secretion ukoroceniem phase, dysfunctional uterine bleeding (with a substitution in the hormone deficiency yellow body), primary and secondary amenorea, kistosnaya grandularnaya giperplazia endometrium, endometriosis, adenomios, suppression of lactation, contraception.

Contraindications

Hypersensitivity, cancer of the breast or genital organs, trombofilicescie condition, including in the history expressed varikoznae changes veins drumsticks and gemorroidalnah veins, holetsistit, hepatitis, human liver functional family giperbilirubinemii (syndromes fell, 12:00-Johnson), liver cancer, skin disease, herpes, severe renal failure, cardiovascular disease, bronchial asthma, epilepsy, pregnancy.

Side-Effects

Nausea, fatigue, parestesia, allergic skin reactions.

Patient interaction

Barbiturates reduce plasma concentration (up metabolism).

Precautions

Prior to the treatment necessary to clarify the cause of vaginal bleeding, it's functional and rule out a malignant neoplasms.

Dosing and Administration

Inside. Treatment fifth paragraph syndrome and mastodinii, 5 mg 16th round of the day for 10 days, with heavy decompensirovanna form and inefficiency, 5 mg, from the 5th round of the day for 21 days. In endometriose for women after 40 years, from 16 to the 25th day of the cycle of 5-10 mg / day for 6 months adenomiose-to 5 mg per day from the 5th-25th day cycle within six months, or ranging from 2.5 mg / day on the 5th day cycle, gradually increase the dose of 2.5 mg every 2-3 weeks for 4-6 months; postponement of the regular menstruation, 5 mg 1-2 times per day, starting 3 days prior to the date of the alleged menstruation, for a period of not more than 10 to 14 days, desfunktionalnogo a mother bleeding on 5-10 mg for 6-12 days, relapse prevention, and 5 mg per day from 16th to the 25th day of the cycle, after the operation at the jeleuzisto-kistoederal hyperplasia - 5-10 mg 16th to the 25th day cycle for a period of four to six months. To prevent breast-October 20 mg, gradually reducing the dose. To contraception only in combination with estrogenami on 1,25-2,5 mg with 1-5-go round of the day for 21 days, then pereraa 7 days.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Norethisterone