Tibolone

Chemical name

(7альфа,17альфа)-17-Гидро кси-7-метил-19-норпрегн- 5(10)-ен-20-ин-3-он

Gross

C21-H28-O2

Of drugs

The drugs act-mode, progestagennoe, androgennoe. Djibouti changing climate гипоталамо-гипофизар��ой system. Impact of opened and LG for women in menopause. The fertile women suppresses Owulatia.posle intake of fast and complete skin, biotransformiroetsa education polar products of their pharmacological remains active. Displays, including and metabolites in urine and Fekaliami.okazavaet catalytic effect on the mucous membrane of the vagina. Prevents osteoporosis, reduces the level of phosphate and calcium in the blood serum. Impact severity klimaktericescoy heart dysfunction (tides, increased sweating, headaches), improves sexual and psihoemotsyonalnoe state (enhances the central and peripheral opioids).

Indications

Menopause (natural and surgical), and osteoporosis estrogenna failure (prevention).

Contraindications

Gormonozawisimae tumours (or suspicion on them), Vaginal bleeding unclear etiology, thrombosis and embolism (incl. history), otoscleros (arising during pregnancy or in the treatment steroidami), a period of less than one year after the last menstrual period, pregnancy.

Side-Effects

The body mass index, headache, dizziness, pain in the back, arms and legs, drumsticks swelling, bleeding from the vagina, seborainey dermatitis, increased hair growth on the face, a change of the liver, endometrium proliferation.

Patient interaction

Do anti effect.

Overdosing

There is a violation of the Jkt.lechenie : symptomatic.

Precautions

There is a need for regular monitoring of laboratory performance in patients with giperholesterinemiei, impaired kidney and diabetes mellitus. It should be borne in mind that, against the background of tibolona possible reduction of the total and free tiroksina and tiroksinswyazawatego globulina.

Dosing and Administration

The inside is not liquid, in the 2.5 mg once a day (at the same time of day). First adopted tablet from the top, obwedennogo a framed set, which marked the day, the day of the reception later in the direction of the arrow. Improvements achieved in a matter of weeks, the best course of treatment three months or more.

Literature

1. T. Rymer, Fogelman J., M. Chapman The incidence of vaginal bleeding with tibolone treatment / / Br. J. Obstetr. Gynecol 1994 .- .- V. 101-N-1 P. 53-56.2. Tax L., M. Goorissen, Kicovic P.M. Clinical profile Liviala (tibolona) / / Mountain. pharmacology and therapy .- 1995 .- V. 4-N 3-C 80-86.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Tibolone