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Tri-regol 21 7

See also Exemestane

Roman name

Tri-regol 21 7

Pharmacokinetics

Levonorgestrel is rapidly absorbed (less than 6700). The levonorgestrel no effect "of a" through the liver. In a joint application with levonorgestrel etinilestradiolom a correlation between dose and C_max in Plazme.t_1/2 is 8-30 hours (average 16 hours). Most of levonorgestrel contact albuminom and globulinom linking sex гормоны.Этинилэстрад��ол quickly and almost completely absorbed from the intestine. C_max plasma is in the range of 1-1.5 hrs T_1/2 is approximately 26 hours Etinilestradiolu share effect "of a" through Pechen.metabolita etinilestradiola are vodorastvorimami products or sulfate conjugation glukuronidna are delivered to the intestine jelchew where by intestinal bacteria are disintegration.

Farmakodinamika

Serial pills products containing different amounts gestagena (levonorgestrel) and estrogen (levonorgestrel), fills and the concentration of sex hormones in the blood, close to the physiological followed by the normalization of menstrual disorders.

Indications

Oral contraception, the functional menstrual irregularities.

Pregnancy and lactation

Contraindicated in pregnancy and during breastfeeding.

Contraindications

Гиперчувствительност ь components products; pregnancy; breast-feeding; severe liver disease; congenital giperbilirubinemii (Gilbert syndromes, and Dubina-jonson fell); cholelithiasis; Whether or in the history of severe cardiovascular and cerebrovascular changes; embolism or predisposition to it; liver tumors; malignant tumours, especially breast cancer surgery or endometrium; Family forms Moyle; severe hypertension; severe diabetes and other diseases endocrine glands; sickle cell anemia; chronic haemolytic anaemia; Vaginal bleeding of unknown etiology; migraine; otoscleros; idiopathic jaundice pregnant women in history; severe skin itching pregnant; herpes pregnant.

Side-Effects

Nausea, vomiting, headache, tension mammary glands, changing body mass and libido, changing mood krovanistye mejmenstruale that, in some cases, uncomfortable to wear contact Linz.redko : to raise triglycerides, blood sugar, lower tolerance to glukoze, the AD thrombosis and embolism venoznae, jaundice, skin diseases, climate vaginal secretions, vaginal candidiasis, increased fatigability, Diarea.oceny rarely (in a lengthy admission) : Hloazma.fumarat iron, which is part of the krasnovato-burah tablets covered by the sugar-coated may create irritatia mucosal blood, nausea, vomiting, diarrhea, constipation and faecal red mass black.

Specific guidance

Apply on doctor's prescription in order to avoid complications.

Patient interaction

The tablets Tri-regol 21 7 requires caution when at the same time as contratsepteve take the following drugs : ampicillin, rifampicin, chloramphenicol, neomycin, penicillin B sulfanilamida, tetratziklin, digidroergotamin, tranquillisers, fenilbutazon because they could relax contraceptive effect at the same time recommended additional, negormonalny contraceptive method; - combined, derivatives or solid indandiona (may need an identification protrombinovogo index and the changes antikoagulyanta dose); - Tricyclic antidepressants, maprotilin, beta-adrenoblokatora (possibly increase bioavailability and toxicity); - oral antidiabetic drugs insulin (may need to change their doses); - bromokriptin (inefficiencies bromokriptina); - drugs with the potential gepatotoksicski by, for example, dantrolen. Hepatotoxicity risk increases with age, especially for women over 35 years of age.

Overdosing

Cases of toxic effects as a result of an overdose of unknown.

Precautions

Before a product, it is necessary to rule out a pregnancy, a general medical examination (AD measurement, laboratory tests of liver function and the level of blood sugar, etc.) and gynaecological examination (the mammary glands, Abriendo analysis of a vaginal swab). During administered such public health and gynaecological examinations should be carried out regularly, every 6 Mes.dla women tromboambolicescimi disease at a young age, or high blood svertavaemostew family history of tablets Tri-regol 21 7 is not �екомендуется.Осторож ность be subject to the availability of diabetes, heart disease, hypertension, a breach of the kidneys, the varicose veins, flebita, otosclerosis, MS, epilepsy, low horei, intermittiruta porfirii hidden tetanii, and bronchial asthma. The oral contraceptive is allowed no earlier than six months after having suffered a viral hepatitis, subject to the full normalization of liver Funksii.pri get sharp pain in the upper abdomen department, and gepatomegalia signs intraabdominalnogo bleeding may occur suspicion of the existence of liver tumors. If necessary, the admission of the drug should be discontinued. In human liver arising from the admission of drug necessary consultation Terpevta.pri you mejmenstrualnah bleeding reception Tri-regola 21 7 should continue, as in most cases these spontaneous bleeding stopped. If bleeding mejmenstruale do not disappear or reappear required medical examination for the exclusion of organic disease reproductive system. Case of vomiting or diarrhoea receiving medication should continue, while applying supplementary negormonalny method of contraception. Women over 35 years of age receiving oral contraceptives should stop smoking because smoking in the face of receiving contraceptive hormone increases the risk of diseases of the circulatory Sistema.za three months before the pregnancy is recommended that the deadline for Preparata.priem drug should stop : in the event of a first or strengthening existing migrenepodobnykh pain, or an unusually severe headaches; Acute deteriorating vision; for the suspicion or coronary heart; with a sharp increase AD; If you have jaundice or hepatitis with jaundice, generalized itching. with increasing seizures; to the proposed transaction (for the six weeks prior to the operation), with a long range; during pregnancy.

Dosing and Administration

Inside, with liquid squeezed few Jidkosti.nachinaya on the first day of menstruation, in the 28 days to take every day for one table. , Preferably at the same time of day. At the reception krasnovato-burah tablets is menstrualnopodobnoe bleeding. The reception tablets in the following packages should proceed without interruption, the after 4 weeks after receiving the drug, on the same day of the week. It is important that the following priority admission tablets : first-6 pink, then five whites, the 10-temno-jeltah, at the end of July-krasnovato-burah. In order to provide the necessary priority on the package marked and numbered arrows. With good preparation Portability take until there is a need for Contratsepce.perekhod to Tri-regolu 21 7 from another oral contraceptive is on the same delivery Sheme.posle reception drug can be recommended only for women, not nursing mothers; You must begin no earlier than the first day менструации.Пропущен��ые tablets : missing pill should be taken within the next 12 hours If after taking the last pill was 36 p, reliable contraception. In such cases, in order to prevent possible mejmenstrualnah bleeding reception preparation must continue the work already started packing, except stick (s) tablets (s). Where timely pass reception tablets recommended supplementary negormonalny method of contraception (eg Barrier). This rule does not apply to pills krasnovato-burogo colors, as they do not contain hormones.

Storage conditions

List B. The temperature 15-30 ° C

Shelf life

5 years

The registration

015002/01-2003

All products of this group