Glucagon

Chemical name

Odnotsepochechny polypeptide consisting of 29 amino acid residues.

Gross

C153-H225-N43-O49-S

Characteristics

Hormone produced alfa-kletkami Langergansa islets; Derived from pojeludochnykh glands of pigs or cattle. White crystalline powder containing less than 0.05% zinc. Virtually nerastvorim in water; Well dissolves at pH below 3 and above 9.5.

Of drugs

The drugs-giperglikemicescoe, skin. Associated with specific receptors on the surface of cells Organs (liver, skeletnaya gym), and indirectly through Gs protein, activates adenilatziklazu-enzyme, transferring ATF Zamf which, in turn, increases the activity fosfaurilaza, raczeplatei glycogen in the liver and muscles to glucose and inaguiruta glikiencintetazu, i.e. glikogenoliz stimulated and glukoneogenez. In other tissues (miocard, smooth muscle) starts second type glukagonovykh receptors increases the concentration of intracellular inositoltrifosfata reduces the intrazellliarnogo calcium and relaxes smooth muscle. However, glukagon has a positive inotroponoe impact on Miocard.t_1/2 is 10 minutes, the degradation glukagona is in the liver and kidneys by enzimaticski proteolysis. Giperglikemicescoe the expression 5-20 min after the / in the introduction, through 15 minutes after the / m introduction, from 30 to 45 minutes after s / to the introduction, the effect of up to 90 minutes. Undergo the following to / in the 0,25-2,0 IU is a 45, followed in / m of 1.0 IU through 10 minutes (4-7 minutes after the dose 2.0 IU). The effect of the on / in a 0.25 IU is 9-17 min (22-25 min dose of 2.0 IU), with the m-a 12-27 min (dose of 1.0 IU) and 21 to 32 minutes (dose of 2.0 IU).

Indications

Hypoglycaemia, gipoglikemical coma, X-ray study autism using barium in a simulated hypotonia, angiography, computed tomography, aderno-magnitny resonance detected bleeding from the small bowel using DNA tehnieciem cells, Hysterosalpingography, intoxication бета-адреноблокатора��и and calcium antagonists, obstruction of the digestive alien bodies.

Contraindications

Hypersensitivity, giperglikemia, insulinoma (perhaps the paradox gipoglikemicescoy reaction), feohromotsytoma (stimulating the release of catecholamines in the blood, can cause hypertension), allergy to bovine and / or Bovine protein.

Side-Effects

Nausea, uncontrollable vomiting, symptoms gipokaliemii (expressed muscle weakness, anorexia, adults, mialgia, convulsions individual groups of muscles), dehydration, allergic reaction (dizziness, refers, skin rash and itching, breathing problems).

Patient interaction

Do indirect effects anticoagulants.

Overdosing

Simptomokomplex includes relentless vomiting, signs gipokaliemii (expressed muscle weakness, anorexia, adults, mialgia, convulsions individual groups of muscles) and Degidratatia.lechenie : symptomatic of a constant monitoring of the content of potassium in the blood. In the case of uncontrollable vomiting a patient rehydration and replenish losses potassium.

Dosing and Administration

Hypoglycaemia : in / in, in / m or m / to put 0.5-1 mg (if necessary, after 12 minutes повторяют).Интоксикац ия beta-adrenoblokatorami : cefuroxim at 0,005-0,15 mg / kg, followed by / with drip Quick 1-5 mg in Cas.intoxication calcium antagonists : one in / in the dose of 2 mg supporting dose individually tailored depending on the status of the digestive Ballogo.obstrukcia reduces body : in / in the 0.5-2.0 mg (if necessary again in 10-12 minutes). Children : mild gipoglikemii produced in / in, in / m or m / to the dose of 0.025 mg / kg body weight, but not more than 1 mg (if necessary, after 12 minutes repeating).

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