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Buserelin

See also Buserelin

Roman name

Buserelin

The composition and the form of

1 orange powder preparation suspension extended release for a / m of the buserelina 3.75 mg; in a cardboard bundle one bottle complete with the solvent in the ampoule 2 ml, single syringe and needle.

Characteristics

Synthetic analogue of the natural гонадотропин-рилизин�� hormone.

Of drugs

Suppress education luteiniziruuchego (causing education yellow body exported) hormone, and thus the synthesis of testosterone (education male sex hormone). The concentration of testosterone in the continued use of the drug for 14 days reduced to the level of the testes (after surgical removal of testicles). The preparation of pharmaceutical castrating (a similar disposal sexual glands). Buserelin well absorbed through the mucous membrane of the nose, in a plasma of high concentration.

Indications

Gormonozawisimy cancer prostate cancer, breast cancer, gormonozawisimaya pathology of the reproductive system due to absolute or relative giperestrogenia (endometriosis, uterine mioma, giperplasticskie the endometrium, infertility).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : insomnia, depression, headaches Bol.so the urogenital system : vaginal dryness, ovarian cyst, the weakening Yeah, the pain at the bottom of the abdomen, menstrualnopodobnoe кровотечение.Аллерги��еские reactions : urticaria, hyperemia skin angioneuroticeski Otek.prochie : increased sweating, tides blood to a person Demineralisation bones.

Patient interaction

The combined application with other property containing sex hormones (for example, induction of ovulation), to a syndrome giperstimulyatsii ovaries. Reduces the gipoglikemicakih funds.

Precautions

To apply caution in patients with depression and for the induction of ovulation (by a physician). Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Home supressivna (in this case is overwhelming, luteinizirutego hormone) therapy : for a period of 7 days a subcutaneous injection of 0.5 mL three times a day through 8 am This corresponds to a daily dose buserelina constituting 0.0015 and continued supressivna therapy : the eighth day there is a move to intranazalnoe (in the nose), the introduction of the preparation. Daily dose of 0.0012 buserelina g, which corresponds to 12 doses of the spray, spread throughout the day. Before breakfast two dose aerosol (in the left and right nostrils), after Breakfast : 2 doses; Before lunch and after lunch-2 doses; Before dinner and after dinner-2 dose, which is equivalent to 12 doses of aerosol in the day.

Storage conditions

por.d / susp.d / in. : List B. In the dark place at a temperature of 20 ° C

Shelf life

por.d / susp.d / in. : 2 grams.

Indications for use

Cancer prostate gland, in cases where shown inhibition (suppression) of the hormone semennikah.

Form of

Solution for injection (1 ml of the drug 0.00105 grams buserelina acetate and benzyl alcohol as a konserwirtego agent) in the bottle. Package 2 bottle of selecting doses of 5.5 ml each, enough to the seven-day course of treatment (21 patients). Buserelin for intranasal use in vials. The contents of the bottle about 100 doses of the spray. One dose aerosol contains 0.00105 grams buserelina acetate.

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