Chorionic gonadotropin

Characteristics

Water glikoprotein, producyruemy platzentoy and derived from the urine of pregnant women. White or almost white sterile liofilizirovanny powder; Stable; As a solution infusions.

Of drugs

The drugs-gonadotroponoe, luteinizirutee. Interacts with specific receptors membrannami (glikoprotein integrated with the molecular weight 194,000) gonad cells, activates adenilatziklaznuu system and reproduces the effects of hormone luteinizirutego front of hypopituitarism. Women induces and stimulates ovulation, helps cut hair and transform it to the yellow body, including in the assisted reproductive techniques; increased functional activity yellow body luteinova phase menstrual cycle lengthens the time of its existence, delaying offensive menstrual phase enhances products and progesterone androgenov, incl. with inadequate yellow body to egg implantation and the development of the placenta. Owulyatsia normally achieved through 32-36 h after injection. Men stimulates the cells testikuliarnah Ladiga increased synthesis and products testosterone, contributes spermatogenezu, development of secondary sexual characteristics and lowering inflammation in Moshonku.horosho absorbed in the blood and in the / m introduction. In a systematic level in the blood slowly increasing and the 7-12 day the original 1.5 times. Has T_1/2 two-phase, 11 and 23 hours Eliminated kidneys unchanged to (10-12% dose within 24 h). Has no mutagenic effects. Dozozawisimo increases the frequency of external congenital abnormalities in the offspring of mice. In appointing pregnant women may have an adverse effect on the fetus.

Indications

Hypothyreosis sexual glands in the гипоталамо-гипофизар��ых violations : from the female infertility due �ипофизарно-овариальн ой palsy, including after the stimulation follikulov maturation and proliferation endometrium, the violation, including the absence of menstruation, dysfunctional uterine bleeding in the child-bearing age, the lack of yellow body, and helped threatening miscarriage in the first trimester of pregnancy-controlled "superovulyatsia" in Artificial Fertilization; for men gipogonadotropony gipogonadizm, El evnouhoidisme, gipogenitalisme, hypoplastic testes, adipozogenitalny syndrome, Violations spermatogeneza (oligospermia, azoospermia), kriptorhizm.

Restrictions on the use of

Polycystosis ovaries (for the induction of ovulation), children up to 4 years (the safety and efficiency to be determined).

Pregnancy and lactation

During pregnancy should take into account the likelihood of an adverse impact on the fruit (according to figures supplied to a pregnant women and experimental animals).

Contraindications

Hypersensitivity, incl. from other gonadotropinam, hypertrophy or pituitary tumors, gormonalnozawisimae tumours or inflammatory diseases of the genital organs, heart and kidney failure, bronchial asthma, epilepsy, migraine; women-syndrome giperstimulyatsii ovaries or threat nediagnostirovannoe desfunktionalnoe breeding bleeding, uterine fibroma, cyst or cancer hypertrophy not related to his policistozom, throm under increasing; for men, prostate cancer cancer, premature puberty (for the treatment of kriptorhizma).

Side-Effects

From the nervous system and sensory organs : headache, irritability, anxiety, fatigue, weakness, депрессия.Аллергичес��ие reactions : skin (type Urticaria, eritematosnaya) angioneuroticeski swelling, Despnoe.prochie : education antibody (with long-term use), in the mammary glands, pain at the site Wvedenia.so the urogenital system : from the female ovaries hypertrophy, education ovarian cyst, giperstimulyatsii syndrome ovaries, mnogoplodnaya pregnancy, peripheral edema; for men, premature puberty, the increase in testicular pahovom channel causing further lowering, degeneration sexual glands, muscle seed channel.

Specific guidance

Solutions are directly to the use of the izotonicescom solution of sodium chloride. It should be borne in mind the possibility of lozhnopolaugitionah immunological analysis of endogenous Chemical and the potential for increased concentration 17-гидроксикортикосте��оидов 17-ketosteroidov and in the urine.

Patient interaction

Coupled with menotropinami urofollitropinom and increases the likelihood of pregnancy and premature birth, the severity syndrome ovarialna giperstimulyatsii.

Overdosing

The women in the induction of ovulation-acute syndrome giperstimulyatsii ovaries (may arise spontaneously at the beginning of menstruation). Symptoms : severe pain in her abdomen (especially in the crotch area), nausea, vomiting, diarrhoea, venous ulcers, reducing diureza, frequent breathing, swelling lower limbs, in the most severe cases - gipovolemia, blood flow, elektrolitny imbalance, liver, peritonitis, gidrotoraks, acute pulmonary insufficiency, embolic Temenia.lechenie : suspension of the drug and, if necessary, hospitalization, Appointment symptomatic therapy to correct water balance, blood clotting and other violations.

Precautions

Treatment out under the supervision of a qualified medical doctor with experience endocrine therapy violations. With the induction of ovulation to individual choice of mode and its correction depending on the performance, regular measurement of seconds and progesterone in the serum, ultrasound ovarian cancer, the daily basal body temperature and the treatment of sexual activity recommended by a doctor. The exaggerated or education ovarian cyst requires suspension of treatment (in order to avoid the gap cyst), abstinence from sexual acts, and reducing doses to the next course. In large thyroid cancer or excessive increase of seconds in the serum in the last day treatment or menotropinami urofollitropinom induction of ovulation in that cycle assessment. During the treatment of infertility in men it is necessary to measure the concentration of testosterone in serum before and after the introduction, the number and mobility of sperm. In early sexual maturation during treatment kriptorhizma therapy supersede and use other methods of treatment. In the absence of a testis down after 10 doses of continued treatment is not recommended. Diagnostics gipogonadizma the boys are under the control of testosterone concentrations in the serum before and the day after treatment (with the normal testicular concentration after therapy should increase 2 times). Improper increase dose or duration of the admission may be accompanied by a reduction in the number of sperm in eyakulyate men.

Dosing and Administration

V / m. Women, for induction of ovulation and in the use of in vitro fertilization : the 5,000 IU a day after the last of menotropinov or urofollitropina or through 5-9 days after the last of klomifena; With inadequate yellow body on the 1500 IU every second day, from the day of ovulation to the day of the expected menstruation or confirmation of the pregnancy (in the latter case may re-use up to 10 weeks of pregnancy). Men, with gipogonadotroponom gipogonadizme to 1,000 IU 2-3 times a week for several weeks or months, or until the therapeutic effect; For the induction spermatogeneza the barrenness within six months or more; if the number of sperm in eyakulyate remains weak (less than 5 million / ml) treatment complement menotropinami or urofollitropinom and continue for a further period of 12 months. Kriptorhizm in prepubertatne age on 1,000 IU three times a week to obtain the desired effect, but no more than 10 doses; Diagnosis gipogonadizma the boys, and 2000 IU once a day for 3 days.

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