Danazol

Chemical name

(17альфа)-Прегна-2,4-диен -20-инo[2,3-d]изоксазол-17-о л

Gross

C22-H27-N-O2

Of drugs

The drugs-antigonadotroponoe. Has expressed reversible (through 60-90 days after admission) antigonadotroponam action combined with a mild, compared with testosteronom, androgennam and Anabolic effects. Stops ovulation. Antigonadotropony effect probably is a suppression release гонадотропин-рилизин��-гормона (GRG), or the suppression of synthesis or release opened and LG glands. The suppression steroidproducyruth enzymes or interaction with steroidnami else in the тканях-мишенях.Биодос тупность not increased in proportion to the increase in dose. The doubling dose plasma concentration of 35-40%. In endometriose damages as normal, and ectopirovannuu endometrialnuu tissue, leading to its inactivation and atrophy. Down syndrome was associated endometriozu is regressive changes endometrioidnykh pockets. Provides immunosupressivne effect and suppressing proliferatiou cells in vitro. It reduces the level of immunoglobulins and IgG production in patients with endometriosis. Changes in cervical mucus and vaginal cytology testing in the employment danazola reflect its overwhelming influence on the гипофизарно-яичников��ю system. In fibrosno-kistosna mastopatii to partial or complete disappearance uzlovatah seals and full kupirovaniu controlling pain. Clinical effectiveness in succession angioneuroticescom oteke possibly due to the higher content of esterase inhibitor S_1 (congenital lack of which is characteristic of the disease) and, as a result, increased plasma levels of S_4 complement.

Indications

Endometriosis, especially retrozerwickalny (in phase II as a self-treatment, in the usual-before and after surgical treatment), benign neoplasms mammary glands, especially fibrosno-kistosnaya mastopatia, menorragia primary, pre syndrome, primary izosexualnoe premature puberty, ginekomastia. Prevention of all kinds (skin, abdominal, laringealnogo) exacerbations in succession angioneuroticescom oteke.

Contraindications

Hypersensitivity, porphyria, cancer breast cancer prostate cancer, genital bleeding (to clarify their reasons), the acute kidney or liver failure, expressed heart failure, diabetes, epilepsy, migraine, violations of plasma hemostasis, pregnancy.

Side-Effects

Violations of menstrual function, a decrease in mammary glands, brutalization vote, the increase in body mass index, oedema, vaginitis, a violation spermatogeneza, alopecia, erythema person sweating, headaches, the vnutricerepnogo pressure lumbalgii, parestesia, nervous reaction, emotional lability, sleep disturbance, depression, the disorder, or trombozitos thrombocytopenia, eritrotsitoz, leucocytosis, increased risk of bleeding in patients with hemophilia increase the transaminaz, holetaz, hepatitis, gepatoadenoma, diarrhoea a (rare), seborrhea, acne, minor girsutizm, allergic skin reactions.

Patient interaction

Changes (not always predictably) effects of steroid hormones, estrogen and progesterone. Increases plasma concentration of antibiotics ziklosporinovogo stimulants. Could increase need for insulin. Do activity противоэпилептически х drugs and anti proximity.

Overdosing

Symptoms : headache, dizziness, tremor, convulsions, nausea, Rvota.lechenie : washing stomach, symptomatic therapy.

Precautions

It periodically monitor the level transaminaz cium and in the serum. In appointing patients with diabetes need a correction insulin dose. During treatment nursing mothers to stop breast-feeding.

Dosing and Administration

Inside, 2-4 times a day. Admission starting on the first day of their menstrual cycle. In endometriose initial dose of 400 mg / day, then - to 800 mg, course-6 months; As a pre-300-400 mg / day for 1-2 months before the operation. In menorragiah and predmenstrualnom syndrome, 100-400 mg / day, a course-3m. In mastopatii-300 mg per day for 3 to 6 months. Children with early sexual maturation daily dose (100 to 400 mg) and the duration of the course chosen a case-by-case basis. To prevent oedema angioneuroticeski initial dose of 200 mg followed by a decline (in the absence of attacks) within 1-3 months.

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