Desmopressin

Chemical name

1-Дезамино-8-D-аргинин-в азопрессинацетат

Gross

C46-H64-N14-O12-S2

Of drugs

The drugs - вазопрессиноподобное . Provides antidiureticescoe act stimulates activity factor VIII blood clotting. Increases permeability membrane distal izvitah channel for the water and increases its reabsorbqiyu. Antidiureticeski effect dispensed with the syringe of the (p / c in / m, / in) and instillation in the nose. Although T_1/2 is 75 minutes, he maintained for a period of 8-20 hours Day and night poliuria disappears after 2-3-kratnogo reception, and in / in a 10 times more effectively than интраназальное.Повыш��ет activity of factor VIII blood coagulability in patients with hemophilia and disease Villebranda : Infusion of 0.4 µ g / kg its rate of 300-400% of the original; is a response within 30 minutes and reaches its maximum (3-4-kratnoe increase) in a half-hour Activity antigen factor VIII and ристоцетин-Ко-факторн ая activity increased to a lesser extent. Desmopressin equally adds factor VIII with mild hemophilia A, Villebranda disease and the healthy volunteers. There is also a rapidly growing concentration plazminoguena without clinically meaningful improvements fibrinolysis.

Indications

Nesharnyi diabetes, acute poliuria, polideepcia after the operation in the field of pituitary, primary nighttime urinary (for intranasal use); For a / in the application, haemophilia A, a disease Villebranda (except for type IIb); Nictoria.

Contraindications

Hypersensitivity, congenital or psychogenic polideepcia, anuria, the delay liquids of different etiology, gipoosmolarnosti plasma, circulatory failure, the need dioretikami therapy. For in / in-the unstable stenocardia, disease Villebranda type IIb, pregnancy.

Side-Effects

Tranzitornaya headache, nausea, spastical pain in the abdomen, disalgomenorea moderate arterial hypertension, tides, a moderate reduction in AD compensatory tachycardia (with on / in the introduction), allergic reactions (including anaphylactic shock); Swelling, local hyperemia, pain at the injection.

Patient interaction

Do effect vazopressornah preparations (to be monitored AD).

Precautions

To reduce the risk of water intoxication and giponatriemii should be limited to the use of liquid (especially for children, adolescents, older people) use liquid. In rinite should appoint subilgvalno (as lost from a broken nose).

Dosing and Administration

Intranasal 10-40 µ g / day in one or more events, children from 3 months to 13 years, 5-30 µ g / Sut.p / to the in / m, / in adults-1-4 µ g / day, the children - 0.4 µ g / sut.

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