Follitpopin beta

Chemical name

Фолликулостимулирующ ий hormone

Of drugs

The drugs-estrogenopodobnoe. Fills gap opened; Adds sex hormones in the blood. Women mature faster follikulov in aicnikah (before predovlatorna stage), the increases estrogen stimulates proliferatiou after Endometria.c_max in / m or m / to the introduction achieved within 12 hours Bioavailability was 77%. The FSQ remained elevated for 48 hours; T_1/2 - 12-70 hours (average 40 hours).

Indications

Infertility among women due гипоталамо-гипофизар��ыми violations (gipogonadotroponam gipogonadizmom), handicapped man hair (lack yellow body); polikistozhnykh syndrome ovaries, refrakterny to medication klomifena zitratom, superovulation induction (IVF fertilization, embryo transfer, the transfer of fusion in matocnuu pipe �нтрацитоплазматичес��ая sperm injection).

Contraindications

Hypersensitivity, or hypertrophy ovarian cyst, uterine bleeding unclear etiology, pituitary tumors and hypothalamus, uterus, ovaries, breast, and fibroma mioma uterus, abnormalities of the reproductive organs incompatible with pregnancy, a primary ovarian failure, extragenital endocrinopathy caused thyroid tumors and cancer napochechnikov, diseases of the thyroid gland, and napochechnikov glands, expressed human liver and kidneys, pregnancy, breast-feeding (at the time of treatment deleted).

Side-Effects

Syndrome giperstimulyatsii ovaries (pain at the bottom of the stomach, nausea, diarrhea, and the development of ovarian cysts, liver, gidrotoraks, tromboembolia, oliguria, gipotenzia) mnogoplodnaya or ectopic pregnancy, fever, arthralgia, pain in the mammary glands, skin rash, urticaria, the formation of antibodies (with long-term use), hyperemia in the injection.

Patient interaction

Klomifena citrate may increase the severity of ovulation stimulation. Sharing agonists гонадотропин-рилизин�� hormone requires increasing dose. Farmatsevticeski inconsistent (not to confuse one sprite) with other drugs.

Precautions

The treatment requires daily hormonal control and examination of the state of the developing follikulov (reaction ovaries can be evaluated using zervikalnomu index). Where there are threats of a syndrome giperstimulyatsii cancer treatment ends. It has changed the place.

Dosing and Administration

B / in (slowly), c / GMT The barrenness initial dose-50-75 IU daily for a period of 7 days, in the absence of a reply ovaries dose gradually increased (with the jet 900 pg / ml override). The reproduction in the first 4 days appoint 100-200 plane, and then an average of 75-350 IU daily for 1-2 weeks.

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