Follitropin alfa

Chemical name

R-hfsh-agglutinin antiresus фолликулостимулирующ ий hormone

Characteristics

White sterile powder that does not contain pirogenov.

Of drugs

The drugs-estrogenopodobnoe. Associated with the receptor in kletkah-misheniah increases estrogen levels and increases proliferatiou Endometria.posle in / in the distribution of fluids vnekletochnykh, T_1/2 in the first phase is 2 p, in the second one-day. The values of the distribution and total Cl are respectively 10 l and 0.6 l / h. 1 / 8 imposed dose displayed with urine. When s / c and / m Russia absolute bioavailability 70%. In reintroduce accumulate over 3-4 days. Equilibrium concentration three times the level of one аппликации.Стимулиру��т follikulov development and ovulation in women with the tail �ипоталамо-гипофизарн ой the system itself or oligomenoreei amenoreei. To stimulate the development of multiple follikulov if necessary superovulation in the case of the technology of artificial reproduction : in vitro fertilization, transplantation gametes or zigota into fallopian tubes.

Indications

Infertility due гипоталамо-гипофизар��ой palsy accompanied oligo- amenoreei or (in combination with horioniceski gonadotropinom); the superovulation (in vitro fertilization and other reproductive technologies).

Contraindications

Hypersensitivity, an ovarian cyst or cancer unrelated to policistozom cancer, gynaecological bleeding ec70 of unknown etiology, cell cancer, uterine or breast cancer hypothalamus or pituitary, the absence of cancer, birth defects of the reproductive organs and tumors of the uterus that are incompatible with pregnancy, occlusion of fallopian tube (possibly of ectopic pregnancy), pregnancy, breastfeeding (a non-breast-feeding).

Side-Effects

Syndrome giperstimulyatsii cancer : pain at the bottom of the abdomen, nausea, vomiting, increased body mass index; Increase or education cyst ovaries, liver, gidrotoraks, embolic phenomena, fever and arthralgia, pain and hyperemia in the injection.

Precautions

Before treatment should be excluded possible causes of infertility, hypothyroidism, adrenakorticalnaya deficiency, giperprolaktinemia, tumors of pituitary and hypothalamus.

Dosing and Administration

P / to the in / m (powder dissolved in distilled water immediately before use; 1 ml can be thinned to 450 IU, which reduces the amount of input). In anovulatornom barrenness conserving menstrual treatment beginning in the first seven days of the cycle. The course must be negotiated with the individual reaction determined by measuring the size of the follikulov ultrasound, and / or estrogen secretions. Daily dose-S 75-150, as required by 7-14 days to increase 37,5-75 IU. If after five weeks is a positive development, the treatment is terminated. After 48 h after the last injection impose one-time dose of NMG-to 10,000 IU. On the day of Chemical injection and the following day to be foxes. In assisted reproductive techniques appoint daily 53.5 IU, starting with the March 2 round of the day, until an adequate follikulov (controlled by the concentration of estrogen in the serum and / or by ultrasound). Dose (maximum 450 IU), according to a response to treatment. After 24 h after the last injection impose one-time dose of human NMG-to 10,000 IU, thus induce final maturity follikulov.

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