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Genotropin

See also Somatropin

Roman name

Genotropin

The composition and the form of

Powder liofilizirovanny for solution for injection (1 ml after смешивания)рекомбина��тный somatotropin (somatropin), 16 IU (5.3 mg) glizin-2 mgmannit-41 mgdigidrofosfat anhydrous sodium-0.29 mgdwunatrievy phosphate anhydrous 0.28 mgm-krezol-3 mgwoda injection before 1 mlv dwuhsekih cartridges (with liofilizatom in one section and the solvent in the other) for ingyektorov Genotropin Pen ®; in a cardboard box 1 or 5 cartridges.

Pharmacokinetics

When s / to a drawn about 80%. C_max, 13-35 ng / J T_1/2 20 to 25 minutes after the on / in and 3-6 h after s / to the introduction.

Farmakodinamika

It stimulates growth and increases the weight.

Indications

Human growth in children : lack of growth hormone (gipofizarnyi nanizm) disgenesia gonad (Shereszewski syndrome, Turner), in pubertatne period with chronic renal failure (compared to a decrease of more than 50%); гипоталамо-гипофизар��ая insufficiency in adults (deficit gipofizarnah hormones, but hormone).

Pregnancy and lactation

Application during pregnancy might be strict testimony in cases where the perceived benefits for a mother than the potential risk to the fetus.

Contraindications

Гиперчувствительност ь (including components solvent); malignant neoplasms; critical condition as a result of open-heart or abdomen, multiple trauma and acute respiratory distress; after a kidney transplant; pregnancy; closure growth zones epifizov tubular bones in childhood.

Specific guidance

When dissolving solution is not ustraherve.

Patient interaction

Impact on the level of cortisol in serum (because of the possible impact somatotropina transport proteins).

Overdosing

Currently, the cases of drug overdose Genotropin were reported.

Precautions

Be wary appoint diabetes (may require correction dose insulin); Nelechennom gipotireoze (to the periodic review of the functions of the thyroid gland, the appointment tireoidnykh hormones); Limp in children gipopithuitarizme (recommended careful monitoring). During treatment should monitor glaznoe bottom (especially when symptoms intracranial hypertension) : swelling drive nerve membranes requires the preparation. Place introduction to be changed to prevent lipoatrofii.

Storage conditions

List B. In the dark place at a temperature of 2-8 ° C. Before raising is permitted to store at room temperature (up to 25 ° C) within 1 month; Ready solution in the refrigerator for 3 weeks. Freezing is not permitted.

Shelf life

2

The registration

008400

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