Kortikotropin

Roman name

Corticotropinum

Of drugs

Hormone formed cells bazofilnykh front of pituitary (gland Endocrine located in the brain). Kortikotropin was a physiological stimulus napochechnikov crust. It is the increasing biosynthesis (education in the body) and in the current blood cortacosteroidnykh hormones (hormones produced cerebral napochechnikov layer), mainly glucocorticoids, as well as androgenov (male sex hormones). At the same time, decreasing maintenance napochechnikah ascorbic acid, cholesterol.

Shelf life

obr.stand. : 2 grams.

Indications for use

Earlier кортикотропин widely used to treat arthritis, infectious nonspecific полиартритов (inflammation of several joints), bronchial asthma, acute and лимфобластного миелобластного leukemia (malignant tumors of blood arising from the blood cells of bone marrow), нейродермита (diseases of the skin caused by the violation of the central nervous system), eczema (нейроаллергического skin characterized мокнущим, зудящим inflammation) various allergies and other diseases. At present, these goals are glukokortikoida apply, as well as non-steroidal drugs (inflammation, protivogistaminne and antiasthmatic drugs, etc.).

Dosing and Administration

Misleading kortikotropin usually in the muscles. The ingestion drug ineffective, as the enzymes destroyed gastrointestinal tract. With the muscle, it is rapidly absorbed. Effects of a single dose lasts for a muscle in the 6-8 hour, and repeat injections 3-4 times per day.

Side-Effects

Using kortikotropina (especially in a long-term high doses), there may be side effects : a tendency to delay in the body of water, sodium ions and chlorine to the development of eye and elevated blood pressure, tachycardia (ucaschenne heartbeats), the excessive increase of protein with a negative balance azotistam, arousal insomnia and other violations of the central nervous system, a moderate girsutizm (excess owolosenie for women reflected growing beards, writing, etc.), menstrual irregularities. There may delay rubtsevania wounds and pitting mucous membrane gastrointestinal tract, the underlying increase in infectious diseases; Children, braking growth. There phenomenon diabetes mellitus, and with the available diabetes increased io (increase in the content of glucose in the blood) and ketos (acidification due to the excessive content in the blood ketonovykh corpses, intermediate products exchange), as well as allergic reactions, which requires the preparation.

Contraindications

Kortikotropin is not suitable for serious forms of hypertensive disease (stable increase blood pressure) and Itsenko-kushinga disease (obesity and the resulting decline in sexual function, increased bone fractures as a result of the strengthened адренокортикотропног о pituitary hormone), pregnancy, circulatory failure III stage acute endocardite (nerve internal cavities of the heart), psihozah, nephrite (nerve kidneys), osteoporosis (eating disorders bone accompanying increase its friability), ulcers stomach and duodenal ulcers, after recent surgery, and AIDS, and the active form of tuberculosis (in the absence of a specific treatment), diabetes, allergic reactions to kortikotropin in history (history).

Form of

In hermetically ukuporennah bottle with a rubber lid and metal tyres containing 10-20-30-40 U kortikotropina.

Storage conditions

List B. In a dry, the dark place at a temperature of no higher than 20 ° C.

Directory → Hormones and their antagonists → Hormones hypothalamus, pituitary, gonadotropin and their antagonists → Kortikotropin