Lanreotide

Chemical name

3-(2-Нафталенил-D-аланил -L-цистеинил-L-тирозил-D -триптофил-L-лизил- L -валил-L-цистеинил-L-тр��онинамид (cyclical 2-> 7 sulphide)

Gross

C54-H69-N11-O10-S2

Of drugs

The drugs - соматостатиноподобно е. Impact liberatiou somatotropina, prolactin, tireotroponogo hormone, and inhibits insulin incretia, glukagona and other biologically active peptides, serotonin, the production of hydrochloric acid, digestive enzymes stomach and pancreas. Released from the microspheres in two phases : a rapid release of peptide (located on the surface) and the slow liberation. C_max in the blood during the first phase (3-10,6 µ g / l), there is a 0,6-2,2 p, and the second (1,4-3,2 g / l), through 0,1-3,7 days. Absolute bioavailability of 29,4-62,8%. The average holding time, 7-9 days. T_1/2 - 2,7-7,7 days.

Indications

Akromegalia, endocrine tumours гастроэнтеропанкреат ической system (symptomatic treatment), complications of operations on the pancreas (prevention), acute pancreatitis, refrakternaya diarrhoea in AIDS patients.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (it is necessary to abandon breastfeeding).

Side-Effects

Anorexia, nausea, vomiting, stomachache, diarrhea, steatorea change tolerance to glukoze violation of the liver, education stones in psoriasis ways (with long-term use), an increase of somatotropina pituitary tumors, pain, itching, burning at the injection.

Precautions

Treatment should be conducted in the specialized agencies. Patients diabetes should be appointed under constant control blood glucose (insulin dose should be reduced, as a rule, 25%). In carcinoid tumors of blood therapy after the beginning of intestinal obstruction; To the traditional gallbladder (every six months). The acute and long steatorei appointment requires enzyme replacement therapy.

Dosing and Administration

V / m. Doses and the introduction of tailored individually. Treatment starts with a test injections (in the case of inefficiency further therapy solution), and evaluate the responses (dynamic secreting growth hormone, symptoms of cancer tissue, etc.). In akromegalia and carcinoid tumors appoint 30 mg every 10 to 14 days.

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