Menotropins

Chemical name

Man Foundation gonadotropin containing opened and LG in the ratio 1:1.

Of drugs

The drugs-gonadotroponoe. Increases the level of sex hormones in the blood plasma. Women promotes maturation in follikulov aicnikah (before predovlatorna stage), raises the level of estrogen, activates proliferatiou endometrium; Men affects Sertoli cells seed channel and produces spermatogenez. Do a steroid hormones sexual disorders. The mainly attributable to the opened. C_max opened achieved through 6-24 h after the / m introduction. T_1/2 - 4-12 hours

Indications

Women : infertility due гипоталамо-гипофизар��ыми violations (gipogonadotropony gipogonadizm), handicapped man hair (lack yellow body), controlled by superovulyatsia ekstrakorporalnom married (in combination with a human NMG). Men : oppression spermatogeneza (azoospermia, oligoastenspermia due to a primary or secondary gipogonadotroponam gipogonadizmom).

Contraindications

Hypersensitivity, tumors гипоталамо-гипофизар��ой area giperprolaktinemia, diseases of the kidneys and pancreas; for women, pregnancy, Denmark and ovarian cyst, polycystosis ovaries, uterine bleeding unclear etiology, estrogenzawisimae tumors uterus, ovaries, breast, uterus mioma, primary ovarian failure, abnormalities of the reproductive organs; for men, prostate cancer cancer or other androgenzawisimae tumors.

Side-Effects

Syndrome giperstimulyatsii ovaries (with the possible development of large ovarian cyst, aszita, gidrotoraksa, embolism, oligurii, hypotension), mnogoplodnaya pregnancy, diarrhoea events (nausea, vomiting), fever, artralgia, mastalgia, ginekomastia (men), skin rash, urticaria (education antibodies with long-term use).

Specific guidance

Not to be confused with other drugs in a single sprite. Men with high blood opened menotropina ineffective. Cooked injection drug use immediately.

Patient interaction

Effect weaken agonists гонадотропин-рилизин�� hormone. Klomifena citrate increases reaction hair.

Precautions

Before treatment should be deleted extra endocrinopathy. During therapy required daily hormonal control and ultrasound developing follikulov (reaction ovaries can be evaluated using zervikalnomu index). Where there are threats of a syndrome giperstimulyatsii ovaries menotropina overturned.

Dosing and Administration

V / m, p / c; Treatment of infertility in women : mean initial dose-75-150 IU opened + 75-150 LG IU per day. After 1-2 days after the last injection introduce 5,000 IU human Chemical. Treatment of infertility in men 75-150 IU opened + 75-150 LG IU / day in combination with 1,000 IU human Chemical; Course-3m.

Directory → Hormones and their antagonists → Hormones hypothalamus, pituitary, gonadotropin and their antagonists → Menotropins