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Minirin

See also Desmopressin

Roman name

Minirin

The composition and the form of

1 tablet contains desmopressina acetate 0.1, or 0.2 mg; in plastic bottles to 30 pcs. , in the box one bottle.

Of drugs

Вазопрессиноподобное . Activates V2-retseptora identity in epitelia izvitah channel and the back part hinges Genle, expands pores epithelium cells nefrona and increases reabsorbqiyu water. Provides antidiureticescoe effect.

Farmakodinamika

In nesharnom diabetes increases reabsorbqiyu water from the distal channel kidneys and increasing the relative density osmoticescuu urine, which is coupled with a decrease in the frequency mocheispuskani and reduced consumption of the liquid.

Indications

Nesharnyi diabetes, primary night enourez children (5 years and older), nictoria (night poliuria) in adults.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus.

Contraindications

Hypersensitivity; State, accompanied by low relative density osmoticescoy blood plasma, incl. psychogenic and polideepcia familiar; delay liquids of different etiology, including chronic heart disease; anuria.

Side-Effects

Headache, nausea, pain in the abdomen, giponatriemia, increased body mass index; Rarely convulsions.

Patient interaction

Increases antidiureticeski effect indometacin and substances that increase the concentration of identity in the body (some antidepressants, chlorpromazine and carbamazepine).

Precautions

Caution must be exercised in the appointment of children and the elderly, with conditions with vodno-elektrolitnam imbalance in patients with increased risk vnutricerepnogo pressure. During the treatment, there is a need to control the volume and mocheotdelenia osmollnosti urine and blood plasma. During treatment enoureza night reception liquid for 1 hour and within 8 h after administration should be limited to a minimum (only for drinking a beverage). In patients over 65 years of age should monitor the level of sodium in the blood before treatment, the three administered, and after the dose.

Dosing and Administration

Inside. Nesharnyi diabetes : in the initial dose of 0.1 mg three times a day and then on 0,2-1,2 mg (maximum). Primary night enourez : on 0.2-0.4 mg per night for 3 months (continued therapy once 1-nedelnogo break). Nictoria : initial dose of 0.1 mg once a day (overnight) the ineffectiveness after one hour dose increased to 0.2 mg / day and in the future for the weekly increase to 0.4 mg / sut.

Storage conditions

table. : In a dry place at room temperature no higher than 25 ° C

Shelf life

table. : 2 grams.

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