Protirelin

Chemical name

5-Оксо-L-пролил-L-гистид ил-L-пролинамид

Gross

C16-H22-N6-O4

Characteristics

White or white with a yellow amorphous white powder. Rat in the water and alcohol.

Of drugs

Drugs, the diagnostic. Rilizing-factor, vrabatawatisa in Hypothalamus, which, through the front of pituitary, contributes tireotroponogo releasing hormone (TTG), and increase the concentration of prolactin. These properties can be used in the diagnosis of hypophyseal insufficiency in patients with gipotireoidnami conditions and women with hypothetical and agalactiei because allows the gipofizarnogo reserve hormone. After the on / in the midst of preparation fostering of the TTG in 20-30 minutes and returned to the original level in a couple of hours T_1/2 short at 5 min.

Indications

Diagnostics hypophyseal insufficiency in patients with gipotireoidnami states hypothetical diagnosis and agalactia women.

Restrictions on the use of

Pregnancy.

Contraindications

Hypersensitivity, organic lesion of central nervous system, epilepsy.

Side-Effects

Fluctuations AD, headache, blindness refers, anxiety, sweating, feeling coma throat, a sense of compression in the chest, pituitary apoplexy, stomachache, xerostomia, unpleasant taste in the mouth, allergic reactions; Redness and soreness at the injection.

Dosing and Administration

Adults : in / in introducing 500 micrograms. A measurement of TTG before and 30 min after Ingyektion.detam : 7 µ g / kg (up to 500 µ g). Time and frequency measurement of TTG are the same as those of an adult.

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