Somatostatin

Chemical name

L-Аланилглицил-L-цисте��нил-L-лизил-L-аспараги��ил-L-фенилаланил-L-фен��лаланил-L- �риптофил-L-лизил-L-тре��нил-L-фенилаланил-L-тр��онил-L-серил-L-цистеин cyclic (1-> 14) disulphide (and in the form of wool pentahydrate)

Gross

C76-H104-N18-O19-S2

Of drugs

The drugs - соматостатиноподобно е. Prevents make growth hormone. The on / in the introduction in plasma is fermentativomu degraded by the action of amino and endopeptidaz. T_1/2 - 2-3 min. Numerous effects from the binding receptors tkanei-michenei. Decreases of blood in the interior organs without causing significant fluctuations AD Systems. It stops the gastrina, gastric juice, pepsina reduces endo- (incl. glukagona) and exosecretia pancreas. Ters irritative stomach and intestines. Will stop bleeding from the upper gastrointestinal divisions (gastric, duodenal ulcer, varikozno advanced esophageal veins) as a result of a significant reduction in blood flow in arteries crevnykh. Effective for the prevention of complications after surgical interventions on the pancreas, in the treatment of pancreatic and intestinal fistula.

Indications

Severe bleeding from the upper gastrointestinal divisions (including the varikozno advanced esophageal veins), fistulas pancreas, jelchne and intestinal fistula (therapy), diabetic ketoacidosis (additional therapy), the prevention of post-operative complications in the surgery to the pancreas.

Contraindications

Hypersensitivity, pregnancy, early post-natal, breast-feeding (should stop breastfeeding).

Side-Effects

Dizziness, a sense of tidal blood to a person (very rarely), aetiology, nausea and vomiting (only at a speed of more than 50 µ g / min).

Specific guidance

Solution physiological solution is stable for 72 h (store in refrigerator).

Patient interaction

Increases effect gistaminovykh H_2-blokatorov (reduction secreta hydrochloric acid), and gexobarbitala pentetrazola (acceleration sleep and sleep extension). Farmatsevticeski inconsistent (in one sprite) with other drugs.

Precautions

Early treatment can develop temporary hyper or hypoglycaemia (blockade secreting insulin and glukagona), which should monitor the content of glucose in the blood every three to four hours, especially in patients with diabetes mellitus. Avoid repeated courses (possible judiciary).

Dosing and Administration

B / 386/1989 After an initial slow (within 3-5 minutes) jet in a shock dose of 250 µ g / h (approximately corresponds to 3.5 g / kg / h) to capelnuu infuziu. Immediately prior to the introduction of the first throw made solvent. Solution for Infusion term (within 12 hours) are using ampoules containing 3 mg active substance and solution of sodium chloride or 5% solution dekstrozy. The recommended perfuzing Syringe pump. When moving between the two infuzyami more than 3-5 minutes (change system for the on / in the perfuzing or syringe pump), produced more slowly in / in infuziu dose of 250 micrograms. After stopping bleeding (through 12-24 h) continuing to be treated within 48 to 72 hours; Is the total length of up to 120 hours In svishchah pancreas, biliary or intestinal continuously introducing dose of 250 µ g / h at the same time as the intravenous nutrition to the fistula and within 1-3 days (to avoid the syndrome of the therapy gradually stop). To prevent complications after surgical interventions on the pancreas being at the beginning of the operation at a speed of 250 µ g / h and a continued for a period of five days. In ketoatsidoze, with a speed of 100-500 µ g / h with insulin (injection test dose of 10 U and simultaneous cefuroxim Quick 1-4,9 U / h). Normalization fast occurs during 6700, and Correction azidoza during 3h

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