Somatropin

Chemical name

Odnotsepochechny polypeptide consisting of 191 amino acid balance (growth hormone Rights)

Characteristics

Sterilized white, or almost white liofilizirovanny powder.

Of drugs

The drugs-somatotroponoe, anabolicescoe, stimulating growth. It stimulates the growth of bone skeleton rights by influencing the plates epiphysis tubular bones, is the increase in the number and size of muscle cells, liver, thymus gland, sex glands, and napochechnikov thyroid gland. Activates hondroitinsulfata synthesis of collagen and increases hydroxyproline excretion increases mass Tela.reguliruet protein-exchange stimulates transport amino acids in the cell and protein synthesis. Decreases cholesterol level increases the number of triglycerides, reduces the amount of adipose tissue. Suppresses the release of insulin and is giperglikemia. Prevents develop liquid nitrogen, potassium, sodium and phosphorus. Loss of calcium (up kidney release) is offset by the increased incidence of autism.

Indications

Violation of the process of growth in children with insufficient endogenous growth hormone, chronic kidney failure in children, accompanied by stunted, Shereszewski syndrome, Turner, osteoporosis, pain syndrome accompanied by the loss of body weight.

Contraindications

Hypersensitivity, malignant neoplasms, the closure epifizov, pregnancy, breast-feeding (at the time of treatment, it is necessary to give up breast-feeding).

Side-Effects

Headache, the vnutricerepnogo pressure accompanied by strong and frequent headaches, nausea, vomiting, visual impairment, oppression of the thyroid gland to the development of symptoms of hypothyroidism, giperglikemia, leukaemia, epifeatheoliz ball of the femur, otechny syndrome; Local reactions, changes in adipose tissue, pain and itching at the injection.

Specific guidance

Some of these drugs are toxic for newborns benzyl alcohol as a dissolution Conservanta.pri not shaking!

Patient interaction

Glukokortikoida inhibit stimulating effect on somatotropina growth.

Overdosing

Symptoms long overdose : gigantism and akromegalia, signs gipersecretii growth hormone; One hypothesis, or giperglikemia.

Precautions

Caution must be exercised in the appointment of the sick diabetics, or patients who have a family predisposition to the disease (possibly increased demand for insulin). There is a need to control the level of glucose in the blood and Moche.u patients with inadequate growth hormone as a result of cancer brain should be more frequent surveys to exclude progression and tumor recurrence Rosta.v period of treatment may develop hypothyroidism and inefficiencies therapy (a periodic monitoring of the functional state of the thyroid gland and adequate substitution therapy tireoidnami �репаратами).Эпифизео��изы heads tubular bones were more common in patients with endocrinal violations, including lack of growth hormone. Hromota discovery in the face of hormone therapy in children requires careful Nabludenia.v case of serious or repeated headaches, visual impairment, nausea, vomiting recommended eye examination floor (fundoskopia) to identify disc oedema eye nerve, and that the possibility of intracranial hypertension. In this case, as far as possible, the treatment of growth hormone. The reappointment required careful monitoring of the symptoms of intracranial hypertension. There is a need to change seats subcutaneous injection for the opportunity lipoatrofi development. The best results are seen in the appointment of care as soon at an earlier age. Treatment continued until puberty and before the closure of bone growth. The termination of treatment in achieving the desired growth.

Dosing and Administration

Preferably n / a and / m. Include product should Medlenno.pri deficiency of growth hormone p / to the 0,07-0,1 IU / kg of body weight (or 2-3 IU / m ^ 2 body surface) 6-7 times a week or / m 0,14-0,2 IU / kg (or 6 IU / m ^ 2) 3 times a week; Shereszewski syndrome - Turner : c / to the 0.14 IU / kg (or 4.3 IU / m ^ 2), 6-7 times a week; chronic kidney failure in children, accompanied by stunted, c / to 0.14 IU / kg body weight (or 4.3 IU / m ^ 2), 7 days a week.

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