Urofollitropin

Chemical name

Cleaned liofilizirovanny powder containing opened and minor amounts of LG, derived from the urine of women in postmenopause

Of drugs

The drugs-estrogenopodobnoe. Фолликулостимулирующ ий hormone responsive to the specific receptor on the surface of the small granuleznah cancer cells and cells in Steroli aickah : these receptors linked to adenilatziklaza through guaninnukleotidnyi regulatory protein (Gs protein). Activating receptors leads to an increase in the concentration of intracellular Zamf and accumulation muthondrialnah enzyme complexes oxidizing long chain cholesterol education pregnenolona (intermediate in the synthesis of female and male sex hormones), the number of which is a function of the content intrazellliarnogo cholesterol. Does gametogenez and maturing follikulov to women, and men regulates spermatogenez (more products androgensvazavatego protein).

Indications

Syndrome polikistozhnykh ovaries (with the highest ratio of LTG / opened and inefficiency therapy klomifena zitratom), infertility aicnikovogo genesis.

Contraindications

Hypersensitivity, the high level opened with primary ovarian failure and asthma disease thyroid and napochechnikov, pituitary tumors, infertility, non-violation of the ovaries, metrorragia etc. bleeding is not the etiology, in the ovaries (except syndrome polikistozhnykh ovaries), pregnancy, breast-feeding (at the time of treatment, it is necessary to give up breast-feeding).

Side-Effects

Diarrhoeal disorders (nausea, vomiting, diarrhoea, pain in epigastralna area flatulence), headache, atelektaza lungs, respiratory distress, necardiogenny black lung syndrome giperstimulyatsii ovaries, embolic complications education multiple cysts in the ovaries, increasing mammary glands, gemoperitoneum, increasing the likelihood of ectopic and multiple pregnancy, chromosomal disorders in the foetus (trisomies 13, and 18 pairs of chromosomes) allergic reactions (skin rashes and itching, alopecia, fever, artralgia, mialgia, weakness), the reactions on the ground of (density, compaction and soreness).

Overdosing

Symptoms : giperstimulyatsii syndrome ovaries (increase cancer, pain at the bottom of the abdomen, nausea, vomiting, diarrhoea, increased body mass index, oligouria, liver, gidrotoraks, gemoperitoneum, gemokoncentration, despnoe) and embolic Oslojnenia.lechenie consists of three phases : I - is designed to reduce the concentration of hormones in the blood and prevent the development of thromboembolitic complications (pneumonia, acute renal failure; it is the on / in the introduction of small quantities of albumin in constant monitoring of electrolytes in the blood and the level of gematokrita. II starts after stabilization of the patient and should lead to a reduction of fluid in body cavities, which in / in introducing small quantities gipertoniceski solution of sodium chloride and albumin. III, which aims to prevent the development of lung inflammation associated with the massive flow of fluids from the body cavities in the vascular course, and includes the use of dioretikov (constant monitoring gematokrita and content of electrolytes in the blood plasma).

Dosing and Administration

B / m (injection prepared immediately before use). There are two patterns of use drugs : a daily dose of 1975 IU during the first 7 days of the cycle menstruiruth women, the second scheme, introducing a day in the dose of 225-375 IU within 1 week. After 48 h after the last dose (regardless of the scheme), one-time injection of Chemical dose of 10,000 IU. With slightly, but no pregnancy a drug can be repeated in one of the schemes for at least another two cycles.

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