L-tirok

Roman name

L-Thyrok #

The composition and the form of

1 tablet contains sodium levotiroksina 50, 100 or 150 µ g; in a package of 50 pieces.

Characteristics

Levotiroksin acting L-tirok substance is a levovreatmati isomer tiroxina (L-T4). Activity 100 µ g L-tirok the clinical significance of the activity of 25 micrograms triyodtironina.

Of drugs

Complementary deficit hormones the thyroid gland.

Pharmacokinetics

Accepted erh, drawn by 70-80% decreased resorption with dietary intake. T_1/2 is 8 days (approximately). One admission on the day of the stable levels triyodtironina (in the body transforms into triyodtironin).

Clinical pharmacology

In the case of cardiac decompensation (as a result of hypothyroidism) L-tirok improves heart function.

Indications

Substitution treatment for all forms of congenital and atrogennom gipotireoze, after exposure of the thyroid gland, tiriodektomii, treatment tireostatikami; Oppression of the thyroid gland in zobe, carcinoma, active adenome (if thyroid gland function remains under control glands).

Pregnancy and lactation

During II and III trimester of pregnancy in order to ensure the adequate steps necessary to increase dose by 25% under the control of L-T4. If hyperthyroidism is not appointed combination L-tirok and antitireoidina because The evolution of congenital hypothyroidism. During the reception improves product may not interrupt.

Contraindications

None.

Side-Effects

Symptoms hyperthyroidism : tachycardia, stenocardia, incredible, nervousness, tremor, sweating, diarrhea, and loss of body weight.

Patient interaction

You can combine with the drugs, shock tireotroponogo secretion of pituitary hormones. Estrogens reduce, and increases phenytoin effect (by increasing or reducing connection with L-tirok tireoglobulinom). Holestiramin reduces induction in the stomach, barbiturates up catabolised preparation. Do the anti reduces activity giperglikemicakih and digitalisa. When taken with tricyclic antidepressants effect mutually reinforced.

Overdosing

Symptoms of acute intoxication (tireotoksicski kriz) - tachycardia, stenocardia, incredible, anxiety, tremor, sweating, diarrhoea, loss of weight. Treatment-reduced dose or discontinue use of the drug for a few days, then resume reception, but in smaller doses. In severe cases, beta-blokatora use. In gipertermii lower temperature patient use / as corticosteroids for the prevention napochechnikova deficiency and plazmaferez, with the expressed intoxication.

Precautions

Before treating patients with secondary gipotireozom because of insufficient glands, it is necessary to take the course kortikoterapii to prevent acute napochechnikova failure. Patients with miksedema and cardiovascular disease (risk of AD, stroke, myocardial infarction, cardiac decompensation) starting treatment with low doses and then, it is very gradual increments.

Dosing and Administration

Inside, on the morning erh, half an hour before meals, every day. Before treatment, the hormone tireotroponogo should be brought to normal. Adults - start with 25-50 µ g / day and gradually increasing dose of 25 to 50 µ g / day over a period of two to four weeks. Contributing dose increased to 200 µ g per day. The plight gipotireoze, strokes, cardiac decompensation, beginning adults from 25 µ g / day or within two days, increasing the dose gradually. Children are starting to 2.5-5 g / kg per day, increasing the dose until a eutireoza.

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