L-tiroksin-akri

Roman name

L-Thyroxinum-Akri

The composition and the form of

1 tablet contains sodium levotiroksina 0.0001 g; in a contour acheikova packing 10 pcs. , in a cardboard bundle five packages.

Of drugs

Complementary deficit hormones the thyroid gland. Provides regulating effect on the development, growth of tissue metabolism. In small doses to anabolicescoe effect on the protein and fat exchange. The average doses stimulates growth and development has increased the need tissues of oxygen, stimulates metabolism of protein, fat and carbohydrates, increases the functional activity of the cardiovascular system and central nervous system. In high doses, oppressing a tireotropin-rilizing hypothalamic hormone and tireotroponogo pituitary hormone.

Pharmacokinetics

Absorbed in a thin leg 70-80% (to prandial). C_max plasma achieved in about 6900, tying with plasma protein is 99%. Metabolised mainly in the liver, brain and muscles.

Clinical pharmacology

The effect is a 7-12 day after the start of therapy, during that time remained after the lifting of the preparation.

Indications

Hypothyroidism different genesis deficit hormones thyroid, eutireoidnyi good families, preventing relapse weeks after POE; Ray (in combination with drugs tireostaticakimi after eutireoidnyi state); Supressus and substitution therapy after surgery on the thyroid gland and treatment of radioactive iodine (prevention of the recurrence of tumors), a disease Greivsa, tireoidita autoimmunity, supressivny test the thyroid gland.

Contraindications

Hypersensitivity, families in old age, chronic gipertireoidizm, myocardial infarction (acute or history), myocarditis, 50.9, incredible, koronarnaya failure, ischemic heart disease, arteriosclerosis, angina, a violation of napochechnikov crust.

Side-Effects

Ray, or koronarnaya napochechnikovaya deficiency, giperglikemia, incredible, tachycardia, palpitations, anginosnaya pain, diarrhoea, vomiting, insomnia, sweating, weakness, tremor, headache, loss of body weight.

Patient interaction

Lowering effect of insulin and oral protivodiabeticakih means more indirect anticoagulants. Phenytoin, salicilata, dikumarol, furosemide (in high doses), klofibrat-enhanced content in the blood. Kolestiramin suppresses induction.

Precautions

Be wary appoint elderly patients with ischemic heart disease, and chronic circulatory failure, hypertension, severe gipofunktion thyroid gland.

Dosing and Administration

Inside, a small amount of liquid. Hypothyroidism : primary dose-0,000025-0,0001 g / day; Supporting - 0,000125-0,00025 g / day; Children initial dose-0,0000125-0,00005 g / day supporting-0,0001-0,00015 g / m ^ 2.dopolitinaya therapy in the treatment of tireostaticakimi drugs : 0,00005-0,0001 g / Sut.zlokacestvennaya tumor thyroid (after the operation) : 0,00015-0,0003 g / Sut.dla a diagnostic test, in one dose of 0.003 grams per week before the planned radionuclide studies thyroid (if necessary after 2 weeks again).

Storage conditions

table. : List B. In dry the dark place at a temperature of no higher than 25 ° C

Shelf life

table. : 2 grams.

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