Liothyronine

Chemical name

О-(4-Гидрокси-3-йодфени��)-3,5-дийод-L-тирозин (in the form of sodium salt or hydrochloride)

Gross

C15-H12-I3-N-O4

Of drugs

Drugs, the lack of complementary hormones the thyroid gland. Increases need tissues of oxygen, stimulates growth and differentiation of tissues, adds bazalnogo metabolism (protein, fat and carbohydrates). In small doses to anaboliceski and in a bigger-kataboliceski effect. Imagine a tireotroponogo hormone. After the intake of 95% of rats for 4 hours The latent period of 4-8 hours The blood firmly binds to proteins. Maximum drug effect occurs in 2-3 days. T_1/2 2.5 days.

Indications

Primary hypothyroidism, miksedema, cretinism, zerebrogipofizarnae disease with gipotireoidnami states gipotireoidne obesity, endemic and sporadic goitre, thyroid cancer, diagnosis of hypothyroidism.

Contraindications

Hypersensitivity, thyrotoxicosis and diabetes, a disease Addison, napochechnikovaya failure, cachexia, IBS.

Side-Effects

Headache, irritability, tachycardia, incredible, stenocardia, cardiac failure, dismenorea, allergic reactions.

Patient interaction

Increases effect of oral anticoagulants, vazokonstrictorov reduces insulin, and other gipoglikemicakih funds. Activity decreases oral contraceptives and holestiraminom. Increases likely side effects of the appointment of antidepressants, cardiac glycosides, ketamina.

Dosing and Administration

In gipotireodnykh states appoint 25 µ g / day may increase dose by 25 µ g every 1-2 weeks. Supporting intake is 75 micrograms. In miksedeme initial dose of 5 g / day increases every 1-2 weeks for a period of 5-10 µ g, and the dose of 25 µ g / day further enhancing produce 5-25 µ g / day every 1-2 weeks. Supporting dose of 50 µ g / sut. In netoksicescom zobe initial dose (5 µ g / d) increased by 5-10 µ g every 1-2 weeks. Maintaining usual dose is 75 µ g / sut.

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