Propitsil

Roman name

Propycil

The composition and the form of

1 tablet contains substances 50 mg and auxiliary substances (lactose, corn and jelatinizirovanny starchy kolloidnyi silicon dioxide, povidon, magnesium stearate); in vials to 20 pcs. , in the box one bottle.

Pharmacokinetics

Once inside propiltiourazil well absorbed from the digestive tract, Cmax in plasma dostigaetca in 1-2 hours Bioavailability is about 80%. After 8 h propiltiourazil no longer detected in plasma, but the duration of the admission to a maximum of one dose of 6-8 hrs This is due to the accumulation of substances in the thyroid gland.

Clinical pharmacology

It has been shown that the frequency of congenital malformations in the treatment tiourazilom no different from the frequency of spontaneous congenital malformations. How thyrotoxicosis, and hypothyroidism in pregnant women is associated with increased incidence of miscarriages, stillbirths and anomalies Razvitia.b last 3 months of pregnancy often spontaneous reduction tireotoxicoza symptoms.

Indications

Thyrotoxicosis (diffuse toxic goitre chemicals adenoma thyroid gland); Preparations for the POE thyroid gland and in the treatment of radioactive iodine.

Pregnancy and lactation

When pregnancy treatment is conducted under strict supervision (level of hormones the thyroid gland should be at the top of the rules tireotropina level should be below normal). B period breastfeeding propiltiourazil as drug of choice, its concentration in breast milk is 1 / 10 of the level in the serum mother (monitoring the newborn, because there had been reports of some cases of hypothyroidism).

Contraindications

Hypersensitivity, lakopenia, agranulozitos, hypothyroidism, active hepatitis, cirrhosis, the liver.

Patient interaction

Tireostaticeski effect decreases while or previous application yodsoderjath drugs or rentgencontrastnykh substances. B, 8c3 the ability of substances to influence the effect of free active fractions propranolola and coumarin derivatives further correction doses of the PP.

Precautions

Bo treatment needed to be monitored on a functional thyroid (identification of tireoidnykh hormones and / or tireotropina blood). The drug is contraindicated patients who have previously experienced heavy side effects in the treatment of propiltiourazilom (agranulozitos heavy defeat liver). The pathological changes in the uniform of the blood and increase the transaminaz Propitsil should be used only under strict supervision of a physician. In the treatment process, it should be borne in mind that development agranulozitoza may occur for a few hours. Since, in most cases, development agranulozitoza not predictable even with constant monitoring morphological picture blood, the patient must be informed of the signs agranulozitoza (fever, malaise, tonzilliarnaya flu, disease) and the need for the immediate study of Krovi.lechenie large doses resulted in the creation or increase existing goitre это следует иметь в виду при интраторакальной локализации зоба (опасность сдавливания анатомических структур в средостении).При сочетании диффузного токсического зоба и беременности Пропицил назначают только в виде монотерапии.

Dosing and Administration

The inside is not liquid, squeezed enough liquids, adults and children over 10 years in the 75-100 mg / day, in the most severe cases, and after previous periods iodine to 300-600 mg (6-12 table. Distributed at the time 4-6 doses); Supporting - dose 25-150 mg / sut. Children from 6 to 10 years initial dose, 50 mg / day, supporting, 25-50 mg / day; Newborns-10 mg / kg / day in ff9 3 admission (in the absence of effective dose increase 1.5-2 times); Supporting dose, 3-4 mg / kg / sut. The interval between meals, 6-8 pm The duration of treatment is determined by individual patient need. Experience with the application shows that the duration of treatment with tireotoxicoza diffuse toxic zobe and toxic adenome thyroid gland should be 1.5-2 years. In patients with renal insufficiency, or in gemodialise correction mode is not required. In Hepatic drug taking in the recommended dose, taking into account the relevant contraindications. When pregnancy Propitsil take the dose as soon lower, in order to avoid attacks, as well as the development of hypothyroidism and goitre in the foetus. In preparation for surgery, or treatment of radioactive iodine duration of the drug to the individual needs Ballogo.esli treatment Propicilom spend on the scheme "and blokiruy zameshchai in combination with tirokshinom Propicila dose should be increased.

Storage conditions

List B. In a dry, the dark place at room temperature

Shelf life

5 years

The registration

011863/01-2000

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