Propylthiouracil

Chemical name

2,3-Дигидро-6-пропил-2-ти оксо-4(1Н)-пиримидинон

Gross

C7-H10-N2-O-S

Characteristics

The white crystalline substance, is a bitter taste, very little rastvorima in water.

Of drugs

The drugs-antitireoidne. Does tireoidnuu peroxydazu and oppressing making ionized iodine in the active form (elementary iodine). Violate salt residue tirosinovh tireoglobulina molecule with the formation of mono-and diyodtirosina and, further, tri-and tetrajodtironina (tiroksin). Ekstratireoidne effect is the application of peripheral transformation tetrajodtironina in triyodtironin. Alleviate or weakens thyrotoxicosis. And zobogennam effect (increasing the size of the thyroid gland), by increasing tireotroponogo secreting pituitary hormone in response to the reduction in the concentration of hormones the thyroid gland in Krovi.u laboratory animals receiving propiltiourazil 80616 registered cases of hyperplasia of the thyroid gland and education Kartsinom.horosho absorbed from the digestive tract and rapidly metabolized. About 35% return with urine, unedited, and in the form of kongugatov within 24 hours Excreted in breast milk (concentration in breast milk is 10 times less than in the mother's blood) can cause hypothyroidism in newborns whose mothers to breast-feeding was propiltiourazil therapeutic doses.

Indications

Thyrotoxicosis (diffuse toxic goitre chemicals adenoma thyroid), the preparations for POE thyroid gland or in the treatment of radioactive iodine.

Restrictions on the use of

Pregnancy, breast-feeding.

Pregnancy and lactation

Perhaps only under strict supervision of a physician.

Contraindications

Hypersensitivity, lakopenia, agranulozitos, hypothyroidism, serious violations of the liver, active hepatitis, cirrhosis.

Side-Effects

Seldom-agranulozitos, pain in the stomach, artralgia, paresthesia, increased thyroid cancer, allergic reactions (skin rash, urticaria); Very rarely (using high doses), liver failure, including tranzitornyi holetaz, thrombocytopenia, limfadenopatia; in some cases, nervno-myshechne disorders, polyarthritis, the taste and smell, vasculit, volchanochnopodobnyy syndrome, nodular periarteriit, nausea, vomiting, dizziness, the eritropoaiza, gemoliz, positive Kumbsa, intersticialnaya pneumonia, peripheral oedema, alopecia.

Patient interaction

Tireostaticeski effect weaken iodized products, including rentgencontrastnye funds. Together with the admission propranololom or coumarin derivatives needed correction their doses.

Overdosing

Symptoms : nausea, vomiting, headache, fever, artralgia, itching, swelling, pancitopenia, agranulozitos, dermatitis, hepatitis, neiropatia, instituting / Deprescia.lechenie : symptomatic treatment, the maintenance of the vital functions; In some cases may wash stomach and the appointment of activated charcoal (to take into account the rapid induction substances).

Precautions

The treatment requires regular monitoring of cellular blood and functional status of the thyroid gland (identification of tireoidnykh hormones and / or tireotropina in the blood). The pathological changes in the uniform of the blood and increase the transaminaz need to consult a doctor. Since agranulozitos can develop within a few hours, the patient must be informed of the signs (fever, malaise, tonzilliarnaya flu, disease) and the need for immediate treatment to a doctor and study of blood. The goiter and hypothyroidism (chronic overdose) Require the Lechenia.pri use during pregnancy and lactation dose should be as low as possible in order to avoid attacks, as well as the development of hypothyroidism or goiter the fetus or newborn.

Dosing and Administration

The inside is not liquid, squeezed enough liquid. Adults and children over 10 years in the 75-100 mg / day, in the most severe cases, and after previous periods iodine to 300-600 mg / day in several events; Supporting - dose 25-150 mg / sut. For children 6-10 years of the initial dose, 50 mg / day, supporting, 25-50 mg / sut. Born on October 5 mg / kg / day in 3 admission (in the absence of effective dose increase 1.5-2 times); Supporting dose, 3-4 mg / kg / sut. The interval between meals, 6-8 pm The duration of treatment is determined individually.

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