Thiamazole

Chemical name

1,3-Дигидро-1-метил-2H-им��дазол-2-тион (okso-forma)

Gross

C4-H6-N2-S

Characteristics

White or yellow crystalline powder with low specific aroma and bitter taste. Easily soluble in water and alcohol.

Of drugs

The drugs-antitireoidne. Does peroxydazu and oppressing the salt tironina education and triyod- tetrajodtironina reduces incretia tiroksina. Lowered the exchange, accelerated withdrawal of thyroid iodine increases retiproknaya activation, and synthesis of gipofizom tireotroponogo hormone, which has been accompanied by some giperplaziei thyroid gland.

Indications

Perturbation toxic goitre school thyroid, Ray (Basedow's disease), disseminirovannaya autonomy of the thyroid gland; Preparations for the operation to the deaths; Preliminary and intermediate treatment therapy radioactive iodine.

Contraindications

Hypersensitivity expressed lakopenia, granulozitopenia, incl. lekarstvenno induced, pregnancy, a very large amount of goitre, a sub-gland, zagrudinnoe location goitre breastfeeding (optional waiver of breastfeeding).

Side-Effects

Nausea, vomiting, the liver, headache, fever, pain in the joints, muscles, lakopenia, agranulozitos, aplastic anaemia, strumogenny effect, hypothyroidism, increase postoperative bleeding thyroid, allergic skin reactions.

Specific guidance

When too early termination possible relapse. Desirable for treatment not regular medical monitoring.

Patient interaction

The effect enhances drugs lithium beta-adrenoblokatora (especially in the run-up to subtotalna tireoidektomii) rezerpin, amiodaron. The risk of hemorrhagic increase amidopirin and sulfanilamida.

Dosing and Administration

Inside, 40-60 mg / day, in light tireotoxicose-30 mg / day (or one in four receiving) in the half hour. Since the eutireoidnyi the dose gradually (on average 3-8 weeks) to reduce maintenance (5-10 mg / day), the admission of which continues within the last two years.

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