Tireokomb

Roman name

Thyreocomb #

The composition and the form of

1 tablet contains levotiroksina 70 µ g, liotironina 10 µ g and potassium iodide 150 µ g; Patients in the 40 pcs. , in the box one bottle.

Of drugs

Co a6da mbined hormone product thyroid and potassium iodide.

Pharmacokinetics

Liotironin (triyodtironin) is faster than levotiroksin (tiroksin), as less linked to the supply of blood circulating in the blood is in a free form and quickly moves through the cell membrane.

Farmakodinamika

Increases need tissues of oxygen, increases energy processes, stimulates growth and differentiation of tissues, affects the functional state of the nervous and cardiovascular systems, liver, kidneys and other organs and systems increased glucose intake and its disposal. The effect is likely to vary depending on the dose : small doses have anabolicescoe to, the big to lead to increased degradation of protein; In addition, high doses tireoidnye hormones inhibit activity tireotroponuu glands. Iodine actively influence the metabolism and increases the inhibition; Especially pronounced effect on the iron schitovidnuu because it is involved in the synthesis of tiroksina. The latent period is liotironina 4-8 hour levotiroksina - 24-48 hours

Indications

Hypothyroidism; Eutireoidnyi families of children and adolescents; Eutireoidnyi diffuse top of the adults and during pregnancy; Prevention of the recurrence of goitre (after POE thyroid gland, or radioactive treatment I ^ 135).

Contraindications

Hypersensitivity, overt and covert Ray, acute myocardial infarction, stenocardia and myocardial infarction in elderly patients, myocarditis, nelechenne of the crust napochechnikov, autonomous adenoma, and fokale autonomy diffuse thyroid (with dosage, the number of iodine is above 300 µ g / day).

Side-Effects

Symptoms of hyperthyroidism (shaky fingers, tachycardia, increased sweating, insomnia, glukozuria, stenocarditicalkie state, the AD of a heart rhythm, diarrhea, loss of body mass index, anxiety); Deterioration of the current disease, the lack of napochechnikov crust.

Specific guidance

There is a need for the constant medical supervision.

Patient interaction

Effect increase phenytoin, salicilata, furosemide, klofibrat reduces - holestiramin (suppresses induction). Do the oral anticoagulants, modifies - protivodiabeticakih funds reduces - tireostaticakih preparations (excess iodine). Ammonium reduces absorption of iodine thyroid problems, Thyrotropic hormone-stimulated.

Dosing and Administration

Inside, if possible prandial. In gipotireoze for 0.5-1.5 table. per day with an increase rate to 3.5 table. ; school-age children initial dose-1/4-G table. daily, then 100-150 g levotiroksina 1 m ^ 2 body surface. In eutireoidnom zobe and for the prevention of recurrence of goitre appoint daily Table 1-3. (children of school age-table 1/2-2). .

Storage conditions

table. : List B. In dry the dark place at a temperature of 15-25 ° C

Shelf life

table. : 3 and

Indications for use

Gipotireoidizm (downgrading of the thyroid gland), tireoidit (inflammation of the thyroid gland), endokrinny exofthalm (mixing eyeball patterns forward, accompanied by the expansion of eye slits / pucheglazosti / associated with metabolic disorders), HIV prevalence retidivirutego (preventing recurrence of goitre).

Form of

Pills in a package of 40 pieces. One tablet contains triyodtironina 0.01 mg, 0.07 tiroksina mg of potassium iodide 0.15 mg.

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