Berlinsulin n bazal u-40

Roman name

Berlinsulin # H Basal U-40

The composition and the form of

1 ml suspension for injection of human insulin 40 and U Protamine sulfate 0.14 mg (equivalent to 0.108 mg Protamine grounds); Patients in the 10 ml, in a Box 1 pc.

Of drugs

Gipoglikemicescoe. Do assimilate glucose tissues facilitates its penetration into the cells stimulates neoglikogenez.

Clinical pharmacology

The starting from 30 to 45 min after injection, reaches a maximum at 10 hours and lasts from 18 to 20 hours

Indications

All forms of diabetes mellitus (I and II type), etc. intolerance insulin preparations.

Pregnancy and lactation

During pregnancy and lactation period, it may be necessary correction dosage of insulin and diet. In teaching trimester reduced demand in the fourth month, it has improved and after childbirth often have quickly diminished.

Contraindications

Absolute : hypoglycaemia, in / in Naznacenie.otnositiona : allergic reactions immediate type of drugs insulin (in history).

Side-Effects

Gipoglikemicakie state (until Tuesday), temporary swelling, the sea aphykia, lipodistrofia, hyperemia (at the injection), allergic reactions.

Patient interaction

Enhancing effect (decline in the demand for insulin) can be done with the admission of alcohol, Alpha and beta-adrenoblokatorov, stimulants, anabolic steroids, klofibrata, ziklofosfamida, fenfluramina, ifosfamida, MAO inhibitors, metildofa, tetracycline and trofosfamida; Relaxation (increase in the need for insulin) - hlorpotiksena, diazoksida, heparin, steroid contraceptives, glucocorticoids, lithium salts, nicotinic acid, fenolftaleina, fenotiazinov, fenitoina, tiazidnykh dioretikov, hormones thyroid, simpatomimetikov, tricyclic antidepressants. Reserpine, salicilata change (increase or decrease) the level lipoglikemii. Symptoms gipoglikemii mask beta-adrenoblokatora and clonidine. Decreases tolerance of alcohol.

Overdosing

There gipoglikemiei : the sudden appearance of sweat, rapid heartbeat, tremor, a sense of hunger, excitement, paresthesia in the mouth, lips, headache, drowsiness, boyazlivosti, depression, irritability, uncertainty movements, the speech and vision impairment. In heavy gipoglikemii, loss of consciousness, cold sweat, the high turgor tissue eyeball patterns, convulsions type Jackson until epistatusa; Babinski.terapia reflex : in light gipoglikemii to receive sugar; In the worst forms should be given / m 2 mg glukagona or glucose (40-80 ml of 40% solution in / w).

Precautions

In case of hypersensitivity to insulinam animal be checked portability human insulin (skin sample). In allergen immediate type Protamine sulphate to go to the heart that does not contain Protamine. Each ingyederovania place of Menaut.neobhodimo prevent product from freezing.

Dosing and Administration

P / to the normally appoint one injection; Dose exceeding 50 U shall appoint two injections a day. Impose dose for 30-45 minutes before the first breakfast and before dinner. In special cases, introducing / m (it is not possible to introduce / w).

Storage conditions

susp.d / in. : List B. In a cool place with a temperature of 2-8 ° C (not freezing)

Shelf life

susp.d / in. : 2 grams.

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