Brinsulmidi p 40 units / ml

Roman name

Brinsulmidi H 40 IU / ml

The composition and the form of

1 ml suspension for injection of insulin human cink-suspenzii 40 U, as well as metilparagidroksibenzoat, sodium acetate, sodium chloride, zinc acetate and water for injection; in glass bottles to 10 ml, in a cardboard bundle one bottle.

Characteristics

Polusinteticeski monokomponennetary insulin Rights containing 30% amorphous and 70% crystalline insulin. Suspension white, and standing rasslaivetsa, forming white residue of liquid sludge transparent colorless or nearly colorless, easily reached with resuspendiruetsa shaking.

Of drugs

Gipoglikemicescoe. Lowers the level of glucose in the blood increases its understanding tissues, activates glikogenogenez, synthesis of protein and lipids, down lipolysis, and glikogenoliz making amino acids into glucose.

Clinical pharmacology

The preparation insulin average duration. The effect is a 2.5 h after s / to the introduction, reaches its maximum in the range of 7-15 hours and lasts 24 hours

Indications

Diabetes mellitus (type 1) in adults, diabetes mellitus (type 2) (in the case of resistance to oral gipoglikemicakim means, including some in the combination therapy; Amidst interkurrentnykh diseases during pregnancy).

Contraindications

Hypersensitivity, hypoglycaemia.

Side-Effects

Hypoglycaemia, allergic reactions (skin rashes, rarely angioneuroticeski swelling); Hyperemia, itching, lipodistrofia (with the long-term use) in the injection.

Specific guidance

Patients receiving more than 100 U / day Brinsulmidi P, in the event of a new drug to госпитализировать.Пе��еход from the same type of insulin on the other should be carried out under the supervision of the level of glucose in Krovi.pri initial appointment, change of insulin, or in the case of the treatment of stress may reduce the ability to drive and mechanisms to other potentially dangerous activities, requiring greater attention and speed Reaktion.pri change the nature and diet, considerable physical loads, infectious diseases, surgical intervention, the occurrence of pregnancy, a violation of the thyroid gland, Addison disease, gipopithuitarizme, renal failure, in patients over 65 years of age must be adjusted Dozu.insulin reduces tolerance to Alkilu.pri to receive any medication should consult with a physician.

Patient interaction

MAO inhibitors, selective beta-adrenoblokatora, sulfanilamida, 25.06.1997, tetratziklin, klofibrat, cyclophosphamide, and fenfluramin preparations containing ethanol, increased gipoglikemiceski effect; Oral contraceptives, glukokortikoida, tireoidnye hormones, tiazidnye dioretiki, heparin, drugs lithium and Tricyclic antidepressants-weakened. Reserpine and salicilata can both relax, and strengthen gipoglikemicescoe effect.

Overdosing

Symptoms : a sharp increase sweating, tachycardia, tremor, a sense of hunger, causing parestesia to the mouth, lips skin, headache; In the most severe cases - gipoglikemical Koma.lechenie : ingesting sugar or foods rich in carbohydrates; In severe cases, loss of consciousness patient-introduction of glucose (40% solution in / in) and glukagona (in / m).

Dosing and Administration

P / to 1-2 times daily, determine dose individually, the use of skin care ustraherve. The preparation should be introduced immediately after entering the syringe. Daily dose of more than 0.6 U / kg should be introduced in the form of two injections in different areas of the body.

Storage conditions

susp.d / in. : List B. In the dark place at a temperature of 2-8 ° C. Avoid freezing

Shelf life

susp.d / in. : 2.5 g.

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