Brinsulmidi csp 40 units / ml

Roman name

Brinsulmidi H 40 IU / ml

The composition and the form of

1 ml suspension for injection contains human insulin-protamina 40 U, as well as 1.6 mg metarezola 0.7 mg phenol, sodium phosphate dihydrate dwuzameshchenny, glycerine as a preservative; in glass bottles to 10 ml, in a cardboard bundle one bottle.

Characteristics

Polusinteticeski monokomponennetary insulin rights in the form of land purchases from Protamine sulphate. Suspension white, and standing rasslaivetsa, liquid sludge on transparent colorless or slightly colored, easily reached with resuspendiruetsa shaking.

Of drugs

Gipoglikemicescoe. Понижает уровень глюкозы в крови, повышает ее усвоение тканями, активирует гликогеногенез, синтез белка и липидов, тормозит липолиз, гликогенолиз и превращение аминокислот в глюкозу.

Clinical pharmacology

The preparation insulin average duration. The effect is a 1.5 h after s / to the introduction, reaches its maximum in the range of 4 to 12 hours and lasts for 24 hours

Indications

Diabetes mellitus (type 1) in adults, diabetes mellitus (type 2) (in the case of resistance to oral gipoglikemicakim means, including some in the combination therapy; Amidst interkurrentnykh diseases during pregnancy).

Contraindications

Hypersensitivity, hypoglycaemia.

Side-Effects

Hypoglycaemia, allergic reactions (skin rash), passing of refraction (usually at the beginning of therapy), and long-term use lipodistrofia-in the injection.

Specific guidance

Patients receiving more than 100 U / day Brinsulmidi inherent in a change of product to госпитализировать.Пе��еход from the same type of insulin on the other should be carried out under the supervision of the level of glucose in Krovi.pri initial appointment, change of insulin, or in the case of the treatment of stress may reduce the ability to drive and mechanisms to other potentially dangerous activities, requiring greater attention and speed Reaktion.pri change the nature and diet, considerable physical loads, infectious diseases, surgical intervention, the occurrence of pregnancy, a violation of the thyroid gland, Addison disease, gipopithuitarizme, renal failure, in patients over 65 years of age must be adjusted Dozu.insulin reduces tolerance to alcohol.

Patient interaction

MAO inhibitors, selective beta-adrenoblokatora, sulfanilamida, 25.06.1997, tetratziklin, klofibrat, cyclophosphamide, and fenfluramin preparations containing ethanol, increased gipoglikemiceski effect; Oral contraceptives, glukokortikoida, tireoidnye hormones, tiazidnye dioretiki, heparin, drugs lithium and Tricyclic antidepressants-weakened. Reserpine and salicilata can both relax, and strengthen gipoglikemicescoe effect.

Overdosing

Symptoms : a sharp increase sweating, rapid heartbeat, tremor, a sense of hunger, causing parestesia to the mouth, lips, headache; In the most severe cases - gipoglikemical Koma.lechenie : ingesting sugar or foods rich in carbohydrates; In the most severe cases, the introduction of glucose (20-40 ml of 40% solution in / in) and glukagona (in / m, c / to, in / in).

Dosing and Administration

P / to 1-2 times daily, determine dose individually, the use of skin care ustraherve. The preparation should be introduced immediately after entering the syringe. Daily dose of more than 0.6 U / kg should be introduced in the form of two injections in different areas of the body.

Storage conditions

susp.d / in. : List B. In the dark place at a temperature of 2-8 ° C. Avoid freezing

Shelf life

susp.d / in. : 2.5 g.

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