Brinsulmidi signs 40 units / ml

Roman name

Brinsulmidi MC 40 IU / ml

The composition and the form of

1 ml suspension for injection of porcine insulin vsokoochischennogo monokomponentny 40 U and 1 mg metilparagidroksibenzoata, as a preservative; in glass bottles to 10 ml, in a cardboard bundle one bottle.

Characteristics

Monokomponennetary vsokoochishchenny pork insulin, a 30% amorphous and 70% crystalline insulin. Suspension white, and standing rasslaivetsa, forming white sludge and transparent colorless or nearly colorless nadosadocnuu liquid sludge easily suspendiruetsa under slight shaking.

Гипогликемическое.Gipoglikemicescoe. Lowers the level of glucose in the blood increases its understanding tissues, activates glikogenogenez, synthesis of protein and lipids, down lipolysis, and glikogenoliz making amino acids into glucose.

Clinical pharmacology

The preparation insulin average duration. The effect is a 2.5 h after s / to the introduction, reaches its maximum in the range of 7-15 hours and lasts 24 hours

Indications

Diabetes mellitus (type 1) of children and adults, diabetes mellitus (type 2) (in the case of resistance to oral gipoglikemicakim means, including some in the combination therapy; Amidst interkurrentnykh diseases during pregnancy).

Contraindications

Hypersensitivity, hypoglycaemia.

Side-Effects

Hypoglycaemia (paleness of skin, increased sweating, rapid heartbeat, tremor); Allergic reactions (skin rashes, rarely angioneuroticeski swelling, it is rarely anaphylactic shock); Hyperemia, itching, lipodistrofia (with the long-term use) in the injection.

Specific guidance

Patients receiving more than 100 U / day Brinsulmidi MCs, in the event of a new drug to госпитализировать.Пе��еход from the same type of insulin on the other should be carried out under the supervision of the level of glucose in Krovi.pri initial appointment, change of insulin, or in the case of the treatment of stress may reduce the ability to drive and mechanisms to other potentially dangerous activities, requiring greater attention and speed of mental and motor Reackzi.pri change the nature and diet, considerable physical loads, infectious diseases, surgical intervention, the occurrence of pregnancy, a violation of the thyroid gland, Addison disease, gipopithuitarizme, renal failure, in patients over 65 years of age must be adjusted Dozu.insulin reduces tolerance to alcohol.

Patient interaction

MAO inhibitors, selective beta-adrenoblokatora, sulfanilamida, 25.06.1997, tetratziklin, klofibrat, cyclophosphamide, fenfluramin, preparations containing ethanol, increased gipoglikemiceski effect; Oral contraceptives, glukokortikoida, tireoidnye hormones, tiazidnye dioretiki, heparin, lithium preparations, Tricyclic antidepressants, weakened. Резерпин и салицилаты могут как ослаблять, так и усиливать гипогликемическое действие.Reserpine and salicilata can both relax, and strengthen gipoglikemicescoe effect.

Overdosing

Symptoms : a sharp increase sweating, rapid heartbeat, tremor, a sense of hunger, causing parestesia to the mouth, lips, headache; In the most severe cases - gipoglikemical Koma.lechenie : ingesting sugar or foods rich in carbohydrates; In the most severe cases, the introduction of glucose (20-40 ml of 40% solution in / in) and glukagona (1 mg in / m).

Dosing and Administration

P / is to determine the dose individually, the use of skin care ustraherve. The preparation should be introduced immediately after entering the syringe. Daily dose of more than 0.6 U / kg should be introduced in the form of two or more users in different areas of the body.

Storage conditions

susp.d / in. : List B. In the dark place at a temperature of 2-8 ° C. Avoid freezing

Shelf life

susp.d / in. : 2.5 g.

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