Insulin, aminoquinuride

Characteristics

Monokomponennetary (chromatographically pure) swine insulin-aminohinurid average duration (10-12 hours).

Of drugs

The drugs-gipoglikemicescoe. Decreases level of glucose in the blood, glukozuriu increases glucose uptake tissues (facilitated its entry into cells). Do synthesis of protein and lipogenez glikogenogenez, reduces the production of glucose liver. Activity begins in 45-60 min after s / to the introduction, reaches its maximum after 2-6 h continues 10-14 hours

Indications

Insulinzawisimy diabetes mellitus (type I), insulinnezawisimy diabetes (type II), with resistance to oral drugs gipoglikemisirutm); Interkurrentne illness or operation in patients with diabetes mellitus.

Contr 596 aindications

Hypersensitivity, hypoglycaemia, insuloma, paragroupova allergy expressed decompensation metabolism.

Side-Effects

Hypoglycaemia, gipoglikemicakie precoma and coma, lipogipertrofia, lipodistrofia, tranzitorne oedema, gipermetropia, raising titra antiinsulinovykh antibodies, allergic reactions.

Specific guidance

It should be borne in mind that during pregnancy increases the need for insulin.

Patient interaction

Gipoglikemiceski effect reinforce MAO inhibitors, selective beta-adrenoblokatora, sulfanilamida and alcohol weakening - oral contraceptives and glukokortikoida, tireoidnye hormones, tiazidnye dioretiki.

Overdosing

Symptoms : Gipoglikemia.lechenie : appointment of glucose inside (if the patient is in the minds), injecting glukagona or glucose (in / in).

Precautions

The issue / 386/1989

Dosing and Administration

P / to the in / m (in exceptional cases) 1-2 times a day for 20 to 30 minutes before eating (place injections change). You can combine with fast insulinami. Dose installed and adjusted individually (but not more than 40 U) depending on the age of the course of the disease and content of glucose in the blood and urine, and diet and physical activity, the availability of infectious diseases, surgical interventions, pregnancy (preferable to use human insulin), the functions of the thyroid gland, Addison disease, gipopithuitarisme, kidney or liver failure. When you komb-insulino S after Insulina-s daily dose can be reduced by 25%, and time should not exceed 40 U.

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