Insuman comb 25 gut

Roman name

Insuman Comb 1925 GT

The composition and the form of

1 ml suspension for injection Insumana Comb 15 TD, 25 TD and 50 TD contains 100 IU insulin, including, respectively, 15, 25 and 50 IU neutral solution insulin, and 85, 75 and 50 IU crystalline insulin protamine, or 40 IU insulin, incl. respectively, 6, 10 and 20 IU neutral solution insulin, and 34, 30 and 20 IU crystalline insulin protamine; in vials to 5 (100 IU / ml) and 10 ml (40 IU / ml) in a cardboard bundle 5 st.1 cartridge devices OptiPen (Insuman Comb 25 TD) has 3 ml suspension for injection of insulin activity 100 IU / ml, incl. 25 IU / ml neutral solution insulin and 75 IU / ml protamine crystalline insulin; in a cardboard bundle 5 pcs.

Characteristics

As a general structure insulino rights and a method of genetic engineering.

Farmakodinamika

Alleviate deficit endogenous insulin.

Clinical pharmacology

Different products are interest ratio neutral insulin and protamine crystalline insulin, which makes quantitative differences in their farmakodinamike. Insuman Comb 15/85 characterized by the rapid onset (from 30 to 45 minutes) and the mean duration (11-20 hours) action Insuman Comb 25 TD, respectively, 60 min and 19 h, Insuman Comb 50/50 to 30 minutes (with a maximum effect at 1-1.5 hr), and 16 h, respectively. The action depends on the dose and the individual patient.

Indications

Caharnyi type 2 diabetes in patients who have not previously received insulin; Pregnant, in the case of lactose etc. insulinsoderjath products; Labilnaya form of diabetes associated with a high titra antibodies to insulino (except Insumana Comb 50 TD); In transplantation ostrovkovh cells pancreas. Caharnyi diabetes type 2, with resistance to oral gipoglikemicakim vehicles at the time of the surgery, at the time of its accession opportunistic diseases, and the ineffectiveness of diet during pregnancy.

Contraindications

Hypersensitivity, hypoglycaemia.

Side-Effects

The impact on carbohydrate exchange : hypoglycaemia (paleness, sweating, palpitations, sleep disturbance, tremor), gipoglikemical precoma and coma; Neurological disorders (rarely); Local reactions : lipodistrofia in the introduction (with the long-term use); Allergic reactions.

Patient interaction

Effect added : ACE inhibitors, acetylsalicylic acid, zibenzolin, fibrata, dizopiramid, fenfluramin, pills gipoglikemicakie means pentoksifillin, fenoxibenzamin, propoksifen, somatostatin, sulfanilamida, amphetamine, 25.06.1997, cyclophosphamide, fenfluramin, fluoxetin, guanetidin, ifosfamid, MAO inhibitors, tetratziklin, tritokvalin, trifosfamid; Weaken : barbiturates dioretiki, danazol, doksazosin, estrogena and progestagena, corticosteroids, glukokortikoida, diaz 18d69 oxid, heparin, isoniazid, nikotinova acid fenolftalein, derivatives fenotiazina, phenytoin, Simpatomimetiki.u patients at the same time receiving clonidine, rezerpin and lithium salts may occur as a weakening or strengthening actions. Impact tolerance of alcohol. Beta-adrenoblokatora, clonidine, guanetidin, rezerpin may mask symptoms gipoglikemii. Can confused with insulinami rights except insulinov intended for pompovogo introduction.

Precautions

In / in a totally unacceptable. Generally, there was a need to reduce the dose of insulin replacement of animal origin in the Insuman Comb.

Dosing and Administration

P / to, the place of injection each time change. Dose set individually. Adults, for the first time receiving medication starts with doses 8-24 IU once a day. Patients with a high sensitivity for insulino may be sufficient dose less than 8 IU / day, with a low-more than 24 IU / sut. The maximum single dose of 40 IU (excess dose of this is permitted only in exceptional cases). Insuman Comb 15 TD and Insuman Comb 25 TD usually do for 30-45 minutes before meals, Insuman Comb 50 TD for 20-30 minutes. In insulinzawisimom diabetes usually appoint Insuman Comb 15 TD and Insuman Comb 25 TD.

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