Protafan hm penfill

Roman name

Protaphane HM # # Penfill

The composition and the form of

1 ml suspension for injection contains biosinteticeski human insulin 40, or 100 IU; in vials of 10 ml or cartridges Penfill 1.5 ml for use in insulinovykh spric-ruckah Novopen 1.5 and cartridges Penfill 3 ml spric-rucki Novopen 3 and Novopen 3 Demi (only 100 IU); in blister packaging 5 pcs.

Characteristics

Monokomponennetary biosinteticeski human izofan-insulin suspension median duration.

Of drugs

Gipoglikemicescoe. Interacts with the specific receptor plazmaticescoy membranes and enters the cell, which activates Tiofat cellular protein stimulates glikiencintetazu, piruvatdegidrogenzu, geksokinazou, ingibiruet lipazu adipose tissue and lipoproteinlipazou. In tandem with the specific receptor facilitates entry of glucose into cells, strengthens its acquisition tissues and promotes the enzyme. Increases Stock glycogen in the muscles, stimulates the synthesis of peptides.

Clinical pharmacology

The effect is a 1.5 h after s / to the introduction, is a maximum 12 hours and lasts 24 hours Protafan HM Penfill insulinzawisimom with diabetes used as a bazalnogo insulin combined with insulin short-acting in insulinnezawisimom-both alone, or in combination with the quick insulinami.

Indications

Diabetes mellitus type I, diabetes mellitus type II (with the resistance derivative sulfonylureas, interkurrentnykh diseases, and operations in the post-period of pregnancy).

Contraindications

Hypoglycaemia, insulinoma.

Side-Effects

Gipoglikemicakie condition, allergies lipodistrofia (with the long-term use).

Patient interaction

Gipoglikemiceski effect reinforce acetylsalicylic acid, alcohol, Alpha and beta-adrenoblokatora, amphetamine, 25.06.1997, klofibrat, cyclophosphamide, fenfluramin, fluoxetin, ifosfamid, MAO inhibitors, methyldopa, tetratziklin, tritokvalin, trifosfamid weakening - hlorprotiksen, diazoxid, dioretiki (especially tiazida) glukokortikoida, heparin, hormonal contraceptives, isoniazid, lithium carbonate, nikotinova acid fenotiazina, simpatomimetiki, Tricyclic antidepressants.

Overdosing

Symptoms : development gipoglikemii (cold sweat, palpitations, tremor, a sense of hunger, excitement, irritability, paleness, headache, drowsiness, and about movements, the speech and vision depression). Heavy gipoglikemii may lead to the temporary or permanent impairment of the brain, coma and death Ishodu.lechenie : sugar, or glucose inside (if the patient is in the minds of), n / a, in the / m or / in-glukagon or / in-glucose.

Precautions

It should not be a drug if mixing suspension is not fully homogeneous.

Dosing and Administration

P / to, the use of the contents of bottle or cartridge (Protafan HM) gently stirred until a homogeneous suspension. Dose is a case-by-case basis. The transfer of patients from vsokoochischennogo porcine insulin on the human dose not change to the translation from bovine or mixed (swine / butterfly), it reduces by 10% (except in cases where the initial dose of 0.6 U / kg).

Storage conditions

susp.d / in. : List B. The temperature of 2-8 ° C. Do not expose to sunlight and freeze. Smart, in zapravljenny spric-rucku must be used within four weeks used cartridge store in the refrigerator, not to sunlight or extreme temperatures.

Shelf life

susp.d / in. : 2.5 g.

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