Beclometasone

Chemical name

(11бета,16бета)-9-Хлор-11,17 ,21-тригидрокси-16-метил прегна-1,4-диен-3,20-дион (and a dipropionata)

Gross

C22-H29-Cl-O5

Characteristics

White or kremovo-bely powder odourless, very little soluble in water; It is readily soluble in chloroform, acetone and alcohol.

Of drugs

Drugs, the anti-inflammatory, protiwallergicescoe, protivooterne, противоастматическое . Has expressed glukokortikoidna and weak mineralokortikoidna activity. In endobronhialnom a slowing migration, and activation of cells involved in allergicescom vospalitionom process (alveolarnae macrofagi) uplotnaet basal epithelial membrane, reduces mucus secretion bokalovidnami cells reduces the number of fat cells in the mucous lining bronchi, relaxes smooth muscles bronchi, reinstates its sensitivity адреномиметикам.Сист��мная Absorption is subject to any form of introduction (endobronhialna, intranasal, ingalciah the mouth). The bonding with blood plasma proteins - 87%. Hydrolyses the esterazami in liver, lung and other tissues with the formation of beklometazon 17-monpirpionata and free beklometazon that have weak противовоспалительно й activity. T_1/2 - 3-15 hours The way excretion (regardless of the method of introduction) as unchanged drug, as well as its polar metabolites from faeces, only 10-15% of the excreted мочой.Терапевтически�� effect develops in 4-5 days from the beginning of treatment and only in a few weeks.

Indications

Bronchial asthma and chronic obstructive lung diseases, allergic rhinitis (seasonal and permanent), vazomotornyi rhinitis, recurrent nasal polyposis, uvenilny rheumatoid arthritis, inflammatory bowel disease, disfonia with systemic red volchanke, persistirutee inflammation middle ear in children, bronholegocnaya dysplasia newborns.

Restrictions on the use of

Systemic infections, tuberculosis, gerpeticescoe defeated eye, II and III trimester of pregnancy.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy. In II and III trimestrah possible if the expected effect therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, I trimester of pregnancy, breast-feeding.

Side-Effects

Ohriplosti vote MEDOSIL feeling in the throat, bronhospasticskie reactions, coughing fits, rinorea, feeling dryness and irritation in the nose, active bleeding, atroficski rhinitis, pitting nasal mucous membrane perforation nose, headaches, dizziness, cataracts, increased vnutriglaznogo pressure, leucocytosis (incl. neitrofilny) limfopenia, eosinopenia, manifestations gipercortitizma, including Kushinga syndrome (using high doses), rotoglotocny candidiasis and aspergillez, nazalny candidiasis, eosinophilic pneumonia, urticaria, angioneuroticeski swelling.

Specific guidance

Before using chlorofluorocarbon time should be to room temperature.

Patient interaction

Increases beta-adrainomimetikov effect. The latter, in turn, reinforce противовоспалительны е beklometazon properties (increase penetration in distale divisions bronchi).

Overdosing

There symptoms гипоталамо-гипофизар��о-надпочечниковой deficiency. Showed temporary transfer to the admission of systemic glucocorticoids, a ACTG.

Precautions

It used to heavily acute asthma attack. In the case of acute asthma attack in response to the use beklometazon, it should be rescinded immediately. The signs гипоталамо-гипофизар��о-надпочечниковой deficiency should continue inhalation, but it is obligatory to the control bazalnogo cortisol in the blood plasma (function �ипоталамо-гипофизарн о-надпочечниковой systems usually normal in 1-2 days). The same control is the use of high doses of beklometazon (1500 g or more). Steps should be taken to prevent the drug from getting into the eyes. Moderate and expressed bronhoobstruguom syndrome recommended for 15 to 20 minutes before inhalation bronhodilatatora use. The treatment of allergic rinita, with abundant mouth droppings, expressed swelling bow moves more while applying sossoudossoujiwath funds. To reduce the likelihood of oropharyngeal candidiasis is recommended that the inhalation of food, and after each inhalation poloskati Rot.pri steroidozawisimoy asthma should use high doses (more than 1,000 micrograms a day). Transfer of patients with bronchial asthma with systemic glucocorticoids action at the 73.21 forms beklometazon dipropionata be implemented gradually : odnomomentnaya not repeal or too rapid decline doses.

Dosing and Administration

Asthma : inhalation, adults-100 µ g 3-4 times a day or 400 µ g twice a day; In the rescue of worsening asthma and steroidna dependency, 250-500 µ g 2-3 times a day with a further gradual reduction in the dose of the control of asthma symptoms. For children 50-100 µ g 2-4 times per day may use as a daily dose of 800 micrograms. Allergic rhinitis : route, adults and children over six years in the 200 µ g into each nostril twice a day.

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