Bekloforte

Roman name

Becloforte #

The composition and the form of

one dose aerosol inhalations for the beklometazon dipropionata 250 µ g; in an aerosol container with a metering valve 80 or 200 doses, in one box container.

Of drugs

Disinfecting, glukokortikoidne.

Pharmacokinetics

In inhalation is a systemic absorption in the lungs and digestive tract (after partial swallowed), unedited, and in the form of active-metabolita beklometazona-17-monpirpionata held by presistemnogo metabolism involving esterz fabric. Absolute bioavailability unchanged beklometazon dipropionata and active metabolita 2%, and 62% (36% absorbed in the lungs, and 26% in the stomach) ingalirovanna dose, respectively. Time to C_max beklometazon dipropionata 0.3 hours; Metabolita active-1 p.m. Linking plasma protein-87%. The distribution for beklometazon dipropionata and active metabolita-20 l and 424 l, plasma Cl-150 l / h 120 l / h, T_1/2 0.5 and 2.7 h, respectively. Excreted mainly in the form of free and kongugirovannah polar metabolites, mostly in faeces (about 60% imposed dose within 96 h) and urine (12%).

Indications

Bronchial asthma in adults and children over 4 years (baseline противовоспалительна я therapy), including in patients with severe disease, with dependence on systemic glucocorticoids.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus and newborn.

Contraindications

Гиперчувствительност ь.

Side-Effects

Ohriplosti, irritation of mucous membrane cut; Bronhospazm paradoxical; Orofaringealny candidiasis, allergic reaction (rash, urticaria, itching, redness and swelling eyes, those lips and mucous membrane mouth and pharynx); Systemic effects : oppression of the crust napochechnikov, osteoporosis, the prevalence of stunting among children, cataract, glaucoma.

Specific guidance

Not intended for cupping the bronchoconstriction.

Patient interaction

Not identified.

Overdosing

Symptoms : lowering the crust napochechnikov (in acute overdose), or suppress its function (with chronic). Treatment : in acute overdose - is not required to chronic-recommended monitoring backup functions napochechnikov crust.

Precautions

In the event of a ohriplosti or irritation of mucous membrane that cut immediately after inhalation rinse mouth and throat disease. To treat candidiasis can be used antifungals local action. It should not be drastically cut treatment. If there is the paradoxical bronchospasm requiring immediate pain it through inhalation bronhodilatator short acts to stop treatment and therapy appoint other drugs. Caution must be exercised in the treatment of patients with active or inactive forms of tuberculosis.

Dosing and Administration

Inhalation. Adults and adolescents aged 12 and above 500 µ g / day in a number of techniques (with bronchial asthma light gravity), 750 µ g / d (at an average gravity), and 1000-2000 µ g / day (severe cases); dose can be gradually increase or decrease depending on the clinical Effecta.detam between the ages of 4 and 12 years in the 250 µ g twice a day (in bronchial asthma moderately), or three times daily (at the grave). Do not use in children with minor illness.

Storage conditions

aeroz.ingal.doz. : List B. In a temperature not exceeding 30 ° C (not freezing)

Shelf life

aeroz.ingal.doz. : 3 and

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