Directory → Hormones and their antagonists → Adrenal → Glukokortikoida → Benarin
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BenarinSee also BudesonideRoman nameBenarinCharacteristicsTransparent, colorless or slightly yellow liquid. A opaleszenzia easy.PharmacokineticsAbsorption low. Once in the blood of the drug completely destroyed (are inactive metabolites) in the "first pass" through the liver. Bioavailability 10% put in the number of stomach and 28% for lung faction. C_max achieved through 15-45 minutes after intranasal. Connection with the plasma protein-88%. The advanced system klirence-84 l / h. T_1/2-2.8 hours C_max - 0.01 mmol / O Return via intestine in the form of metabolites 10%, memory 70%.IndicationsSeasonal and year-round allergic rhinitis.Pregnancy and lactationContraindicated in pregnancy. At the time of treatment should stop breastfeeding.ContraindicationsГиперчувствительност ь to components of the preparation, fungal, bacterial and viral infection of the respiratory system, tuberculosis of the respiratory organs, pregnancy, breast-feeding.Side-EffectsBurning, eye irritation nose, sneezing, kandidomikoz.Specific guidanceRecommended to avoid contact with eyes.Patient interactionPhenobarbital, phenytoin, rifampicin reduces effectiveness (induction enzymes mikrosomalnogo oxidation). Metandrostenolon, estrogena reinforce the budesonida.OverdosingWith long-term use of high doses, as well as at the same time admit other systemic corticosteroid may appear gipercortitizma symptoms. In this case, the admission Benarina should stop, gradually reducing the dose.Dosing and AdministrationIntranasal. Adults and children over the age of 18, one-time dose (depending on the severity of the disease), 60 µ g, 2-3 drops in each of the bow. Daily dose chosen individually in the light of the gravity of the current rinita usually enough time two doses a day. The duration of 10-14 days, depending on the gravity of Rinita.maximalnaya single dose of 200 micrograms (100 micrograms in each of the bow), the maximum daily dose is 400 micrograms for a period of not more than 3 months.Storage conditionsIn the dark place at a temperature of no higher than 25 ° CShelf life2The registration002836/01 |
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