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BiastenSee also HalometasoneRoman nameBiastenThe composition and the form ofPowder for inhalations dose-1 dozabudesonid-100 mcgsalbutamola gemisuktinat-200 mcgnatria benzoate 9.7 megawatts plastic package one inhaler "Ziklohaler" 100 or 200 doses; In a box one package.CharacteristicsMelkochristalliceski powder white, or nearly white.PharmacokineticsBiasten bioekvivalenten the monopreparatam against systemic exposure budesonida and salbutamola gemisuktinata.FarmakodinamikaCombined preparation containing glukokorticosteroid for local applications (budesonid) and the selective beta_2-adrainomimetik (salbutamola гемисукцинат).Будесон ид is �люкокортикостероидн��м produced with the local high and low systemic pharmacological activity. Provides protiwallergicescoe, противовоспалительно е and antiekssoudativoe action that the inhalation method of the results in the reduction of bronchial Obstruktion.mehanizm action is to oppression release mediators of inflammation and allergies, as well as to reduce the reactivity smooth muscles bronchi. Budesonid prevents attacks of asthma, but not bronhospazm dosage. Therapeutic effect develops gradually over 7-10 Dnei.salbutamola gemisuktinat is a highly selective catalyst бета_2-адренергически�� receptors. Has expressed bronhodilatirutm act and warns dosage bronhospazm reduces resistance in the respiratory passages, increases vital capacity lungs. Prevents the gistamina slowly responsive substance from fat cells. Bronchodilatory effect comes quickly within 1-3 min after inhalation, and lasts for 5-7 h after administration of a single dose. In therapeutic doses salbutamola gemisuktinat virtually no hronotroponogo and inotroponogo effects.IndicationsBronchial asthma (as a baseline therapy when clinically justified use of a combination of drugs : glukokorticosteroida inhalation and selective бета_2-адреномиметика) .Pregnancy and lactationApplication of pregnancy (see Contraindications), and during the period of breast-feeding may only when the intended benefits to the mother outweighs the potential risk to the fetus or child.ContraindicationsHypersensitivity to the components of an active form of pulmonary tuberculosis; Fungal, viral, bacterial infection of the respiratory system, pregnancy (I and II trimenon), the threat of cancer, the age of children up to 16 years of age.Side-EffectsIrritated mucous membranes of the oral cavity and pharynx, cough, ohriplosti vote (disfonia) and afonia, kandidozny stomatitis and pharyngitis, dry mouth, unpleasant taste in the mouth, nausea, Rvota.v rare cases, a sense of internal anxiety and weak tremor skeletal muscles, headache, arterial gipotenzia, collapse, rapid heartbeat, paradoxical bronhospazm, skin Sapi.vozmojna neurological symptoms : Increased nervous anxiety, depression, insomnia, a breach of conduct.Specific guidanceOhriplosti vote cough as a result of subsidence in preparation rotoglotke due to the inhalation technology usually comes in the wake of reducing dosage. Local infection caused by fungi drojjepodobnami quickly kupiruyutza local anti treatment without interfering with the treatment Preparatom.vo avoid candidiasis development of the oral cavity and pharynx to the inhalation well propolasquivati mouth water (water not swallow). Switch from systemic глюкокортикостероидо в at Biastena inhalation may cause allergic reactions such as rhinitis and eczema, which have hitherto been suppressed system �люкокортикостероида��и. When these symptoms should antigistaminnah 1c43b appointment and / or drugs with the local operation for the treatment of the Zabolewanyi.vo some of the systemic глюкокортикостероидо в at 73.21, patients may experience increased fatigue, headache, muscle and the joint pain, and sometimes nausea and Rvotu.v rare instances (with the full lifting pills �люкокортикостероидо��) may be symptoms caused by the systemic effects of oral glukokorticosteroidov, including gipofunktia napochechnikov depending on the size of dose taken, the duration of treatment, side or prior glukokorticosteroidov reception, as well as individual sensitivity.Patient interactionUnknown clinically meaningful interaction budesonida belonging to the drug Biasten with other drugs used in the treatment of asthma. Caution must be exercised while appointing Biastena and enzyme inhibitors CYP3A4 (eg ketokonazola, ritonavira), as the system can budesonida повышаться.Сальбутам��ла gemisuktinat who is a member of the Biastena, dovetails with the �ротивоастматическим�� drugs other pharmacological groups ( глюкокортикостероидн ые hormones, membranostabilizatora, antihistamines, otharkiwate means mukolitiki, holinolitiki, xantinove derivatives). is not recommended at the same time use Biasten and selective blockers beta-adrainoretseptorov such as �ропранолол.Гипокалие мия can be reinforced by the simultaneous application of salbutamola gemisuktinata belonging to the drug Biasten and derivatives xantina, glukokorticosteroidov, dioretikov.PrecautionsThe agent is appointed with caution to patients with tahiaritmiei and other violations of rhythm, miocarditom, congenital heart defects (including aortalnam stenosis), gipokaliemiei, arterial hypertension, severe heart failure, diabetes, thyrotoxicosis, glaucoma.Dosing and AdministrationBiasten not intended for the initial selection of therapy in the early stages of the treatment of asthma. Selection of doses of drugs that are members of the Biastena (budesonid and salbutamola gemisuktinat) will be done individually, and depending on the severity of the disease. After sustained remission reception monopreparatov replaced Биастеном.Рекомендуе��ые dose : 1 inhalation three times a day or two inhalations twice Sutki.posle attain optimal control symptoms of asthma in the face administered to reduce daily intake Biastena to the lowest effective dose of supporting up to the reception every day. In applying the product should comply with instructions on the use of ingalatora "Ziklohaler."Storage conditionsIn dry, the dark place at a temperature of no higher than 25 ° CShelf life3 yearsThe registration002287/01-2003 |
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