Budenofalk

Roman name

Budenofalk #

The composition and the form of

1 capsule mikrosferami-resistant Effects gastric juice contains budezonida 3 mg; blistere in 10 pcs. , in box 5 blisters.

Of drugs

Противовоспалительно е. Assists мембраностабилизирую щее Effects reduces the mediators of inflammation (lakotrienov and prostaglandines) from the fat cells bazofilov and macrophages. Have a high affinity to specific receptors glucocorticoids, mainly through local antiinflammatory, protiwallergicescoe, antiekssoudativoe and protivooterne effect.

Pharmacokinetics

Rapidly absorbed in the gut. Once inside C_max is 90 min. About 90% of the absorbed budesonida metabolized in the first pass through the liver, the rest of about 90% is associated with albuminom located in the down state. Return with urine, partly from jelchew as inactive metabolites.

Indications

Krone disease involving lymph and / or ascending colon obodocna (for the induction of remission with light and heavy forms).

Pregnancy and lactation

Perhaps only if the expected benefits of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, gastrointestinal infections (bacterial, fungal, amebnye, viral), serious violations of the liver, breast-feeding, child.

Side-Effects

From the nervous system and sensory organs : depression, euphoria, irritability, glaucoma, Katarakta.so the circulatory system and blood (blood, gemostaz) : arterial hypertension, increased risk tromboobrazovania, Vasculit.so part of the intestine : jeludochny discomfort, duodenale canker Pankreatit.so the endocrine organs : Kushinga syndrome, declining function or bone cortex Napochechnikov.so the musculoskeletal system : muscle weakness, osteoporosis, aseptic necrosis Kostei.so the Skin : allergy exantema red pigment, petehii, ekhimoz, societies face, the deterioration healing Ran.prochie : increased risk of infectious diseases.

Patient interaction

Inhibitors zitohroma P450 (ketokonazol, troleandomitin, erythromycin, ciclosporin) added effect. Increases of cardiac glycosides (due to a deficiency of potassium); Saluretiki increased excretion of potassium.

Precautions

With the utmost care appoint patients with arterial hypertension, diabetes, osteoporosis, tuberculosis, pepticescoy cancer, glaucoma, cataracts (need special medical supervision). In the case of wind smallpox and measles should be treated with immunoglobulinami and appoint antivirals. It may suppress the гипоталамо-гипофизар��о-адреналовой system and reduce the response to stress.

Dosing and Administration

The inside is not liquid (if there is a violation of glotania can open the capsule and swallow all microspheres), squeezed enough liquid (full glass of water) for 30 minutes before eating, 3 mg three times a day (morning, noon and evening). Exchange-2-8 weeks.

Storage conditions

caps. : List B. In dry the dark place at a temperature of no higher than 25 ° C

Shelf life

caps. : 3 and

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