Budesonid

Roman name

Budesonide

The composition and the form of

one dose aerosol inhalations for the budesonida 50 µ g (photo), or 200 µ g (Fort); bottle of 10 ml and 200 doses, in a carton 1 pc.

Of drugs

The substance-budesonid, is negalogenizirovannam glukokortikoidom (hormone crust napochechnikov affecting carbohydrate and protein exchange) prednizolonovogo stimulants. The intensity of local prednizolonu par. Suction occurs more slowly from ointments than cream, the effect is a long time, so the materials better for the treatment of chronic processes.

Pharmacokinetics

After inhalation in the lungs is not metabolised. Received by the blood of almost entirely (90%) down to the "first pass" through the liver : active metabolites of 1% of the total content. C_max achieved through 15-45 minutes after inhalation introduction. T_1/2 is 2.8 hours System bioavailability of 23%. Return with urine, in part jelchew.

Clinical pharmacology

Suppress nespecificescuu giperreaguosti bronchi in patients with bronchial asthma and improves the lung function and respiratory system. In therapeutic doses (0,2-1,6 mg / day) did not have a negative impact on гипофизарно-надпочеч��иковую system, and it is changes in the concentration of cortisol in the blood; prolonged use (over 12 months) in children does not alter the growth rate and weight.

Indications

Bronchial asthma.

Pregnancy and lactation

Perhaps if the expected benefit to the mother outweighs the potential risk to the fetus.

Contraindications

Viral, bacterial, Fungus infection in the skin layers, tuberculosis skin sifiliticescoe skin change an zoster, perioralny dermatitis (inflammation of the skin around the mouth). Pregnancy, breast-feeding are relative recommandations. We use for the treatment of eyes and the surrounding skin, and mucous membranes

Side-Effects

Rarely can be bleeding under occluzionna bandage. With long-term use in the same area, especially among young people, may be insufficient (thinning) skin. Rarely secondary superinfection (heavy, rapidly evolving forms of infection as a result of the decline in defence organism under the influence of drugs), erupce (skin irritation) like ordinary teens, a sense of stinging, itching, emptying on the skin, folliculitis (inflammation of hair bulbs), gipopigmentation (weakening of the natural skin colour), stripes on the skin, gipertrihoz (excess of hair cover, not proper age and sex).

Dosing and Administration

Inhalation, determine dose individually, depending on the severity. Adults : by 1-2 dose (Forte) two times a day. The highest daily intake of 1.6 Mg.detam : by 1-2 dose (photo), 2 times a day. Higher daily doses of 0.4 mg.

Storage conditions

aeroz.doz.forte : In a cool protected against overheating and fire mesteaeroz.doz.mite : In a cool protected against overheating and fire site

Shelf life

aeroz.doz.forte : 2 g.aeroz.doz.mite : 2 grams.

Indications for use

Inflammatory skin diseases responsive to corticosteroids (hormones napochechnikov crust), especially atopic dermatitis (skin disease resulting from the violation of the nervous system, characterized by the formation of small zudaschei disease at symmetrically arranged skin surfaces face, neck, as well as in the rear passage and genital organs), psoriasis, eczema (neiroallergicescoe skin disease characterized moknushim, zudahim inflammation).

Form of

Ointment in trying to 15gu.

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