Budesonide

Chemical name

(11бета,16альфа)-16,17-[Бут��лиденбис(окси)]-11,21-ди��идроксипрегна-1,4-диен - 3,20-dion

Gross

C25-H34-O6

Characteristics

White or no white powder, odourless, virtually nerastvorim in water and geptane, sparingly soluble in ethanol, it is readily soluble in chloroform.

Of drugs

Drugs, the anti-inflammatory, противоаллергическое . Oppressing synthesis lakotrienov and NG inhibits products Cytokines, warns migration and activation of inflammatory cells, increases the sensitivity of бета-адренорецепторо�� smooth muscle Bronhov.posle inhalation in the alveolus up about 25% of the doses. Once in the blood of almost entirely (90%) down (there inactive metabolites) in the "first pass" through the liver. Bioavailability of 10% of the revenue in the number of stomach and 28% for lung faction. C_mah blood achieved through 15-45 minutes after inhalation or intranasal. Linking plasma protein is 88%. The advanced system Cl (84 l / h). T_1/2-2.8 hours Return with urine, partly from jelchew as inactive метаболитов.Резорбци�� budesonida of materials has been slower than creams, and the effect persisted for a longer time, so therapy of chronic preferable to use ointment. And local sossoudossoujiwatmi properties normalizes vascular permeability, lizosomaiona stabilize membranes and ingibiruet cell migration vospalitionuu Tkany.pokazana effectiveness budezonida (oral product formulation) in inflammatory bowel diseases, including with a rounded involving lymph and / or ascending colon obodocna (for the induction of remission with light and heavy forms), collagenoznom kolite.

Indications

Bronchial asthma, chronic bronchitis obstruguy, atopic dermatitis, psoriasis, eczema.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (at the time of treatment should be suspended breastfeeding); For local applications : viral, fungal, bacterial (including tuberculosis) infections of the skin, an zoster, rosazea; For the inhalation of use : active form of pulmonary tuberculosis, fungal infections of the respiratory system.

Side-Effects

Locally : bleeding, skin atrophy, superinfection, dermatitis, tinea, gipopigmentation, nurturing, gipertrihoz, papulezny dermatitis, a stinging, itching, systemic effects of glucocorticoids (for the long occluzionna bandages); In ingalciah : disfonia, sore throat, throat irritation, cough.

Precautions

Ointment and cream can be on the mucous membranes (Avoid contact with eyes). With long-term use may develop candidiasis.

Dosing and Administration

Nakozhno the depressed area are thin layer of ointment or cream 1-2 times a day; In the maintenance therapy-1 once a day for 4 weeks (maximum). Inhalation : adults (the highest daily dose of 1.6 mg), a photo budesonid to 1-4 doses twice a day, budesonid Fort 1-2 dose two times a day, the children (the highest daily dose of 0.4 mg), a photo budesonid on 1-2 dose twice a day.

Literature

1. Masevic Z.G., Sitkin SI Current pharmacotherapy of chronic inflammatory bowel disease / / Aqua Vitae - 2001 - N-1 37-41.2.Baert C. F., A. Schmit, D'Haens G. et al. Budesonide in collagenous colitis : a double-blind placebo-controlled trial with histologic follow-up / / Gastroenterology-2002 - N-122 P. 20-25.

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