Cortisone

Chemical name

17,21-Дигидроксипрегн-4-��н-3,11,20-трион

Gross

C21-H28-O5

Characteristics

White or white with a yellow-brown crystalline powder. Nerastvorim almost in the water. Very little is soluble in alcohol.

Of drugs

Drugs, the anti-inflammatory, desencibilizirutee, protiwallergicescoe, immunodepressivne. Glukokortikoid. Противовоспалительны й effect from oppression fosfolipaza A-2, which leads to the synthesis of braking GHG reduction of macrophagic hemotaksicski factor reducing migration macrophages and lymphocytes in the center of inflammation, stabilize membranes lizosom and prevention of lysosomal enzymes. Immunodepressivne effect due to a reduction of immunocompetent cells, a decrease in binding immunoglobulins with cell receptors, down blasttransformation B-limfozitov decline of interleukin, limfokinov circulating immunokompleksov, complement fractions. The delay sodium and water, increases withdrawal potassium. Increases down calcium in urine, activates lysis bone by breaking up the numbers calzitonina increases activity osteoclastov reduces - osteoblastov. Enzyme catalyst of the liver, glukoneogenez activates and increases the concentration of glucose in the blood. With kataboliceski action increases the breakdown of proteins. Provides lipoliticescoe act increasing the fatty acid in the blood. Impact a front ACTG shares glands (the principle of negative feedback), which leads to suppression of incretii and subsequent degeneration napochechnikov crust. After the / m of slowly absorbed. Is rapid transformation in the liver, kidney, peripheral tissues with the formation of active metabolites, excretiruthan, mainly kidneys. Maximum pronounced biological effects through the 20-48 hours

Indications

Acute malnutrition napochechnikovaya, anaphylactic shock, angioneuroticeski swelling, myalgia, arthritis, kollagenozy, revmocardit, bronchial asthma, dermatitis, haemolytic anaemia, Verlgofa disease, chronic active hepatitis, gepatonekros, lymphoma, breast cancer, prostate cancer cancer, principally syndrome, male, inflammatory syndrome any genesis, lakopenia.

Restrictions on the use of

Pregnancy, breast-feeding.

Contraindications

Myocardial infarction, heart failure, arterial hypertension, a disease hospital stomach and duodenal ulcers, increased bleeding, osteoporosis, diabetes mellitus, viral and fungal infections, tuberculosis, otkratougolnaya glaucoma, a breach of the liver and kidney pathology thyroid, гиперчувствительност ь.

Side-Effects

Arterial hypertension, edema, heart failure, arrhythmia, ulcerative defeat mucosal blood, bleeding from the intestine, osteoporosis and spontaneous fractures, steroidnyi diabetes, syndrome Kushinga, mialgia, artralgia, atrophy of muscles, allergic reactions; Redness and pain at the injection.

Patient interaction

Do the anti, antiagregantov, side effects NPVS, cardiac glycosides, estrogen, and androgenov anabolic steroid, amfoteritina B asparaginaza. Impact gipoglikemicakih efficiency, and gipotenziveh mochegonnah funds.

Dosing and Administration

Inside, the initial dose-200 mg in 2 admission (morning and afternoon). When a dose effect gradually reduced to a supporting-25 mg / sut. The / m imposed on 25-50 mg 1-2 times a day. Higher doses for adults : single 150 mg daily to 300 mg. For children initial dose of 12,5-25 mg twice a day. Supported dose selected individually.

Directory → Hormones and their antagonists → Adrenal → Glukokortikoida → Cortisone