Flunisolide

Chemical name

(6альфа,11бета,16альфа)-6- Фтор-11,21-дигидрокси-16,1 7-[(1-метилэтилиден)бис (окси)]прегна-1,4-диен-3,2 0-дион

Gross

C24-H31-F-O6

Of drugs

The drugs - противовоспалительно е. Violate metabolism arahidonova acid and synthesis lakotrienov and NG. After inhalation 1 mg bioavailability is about 40%, since is the rapid transformation in the lung of education сигма-бета-гидрооксим етаболитов and metabolizmu first passage "through the liver. The high presistemnogo metabolism when administered bioavailability even lower. It accumulates in the body, even with the admission of the maximum doses. T_1/2 1.8 hours Reduces the permeability mikrososudov, ingibiruet production and secretion of Cytokines, prevents direct migration and activation cell inflammation increases the sensitivity beta-retseptorov smooth muscles of the bronchi beta-adrainomimetikam.

Indications

Bronchial asthma, chronic bronchitis obstruguy, allergic rinita.

Restrictions on the use of

The ulcers nose, bow recidivating bleeding in operations or nose injuries.

Contraindications

Hypersensitivity, viral, bacterial and fungal infections of the mouth and bronchi, active tuberculosis, pregnancy (I trimester), children's age (up to five years).

Side-Effects

Rotoglotocny candidiasis, disfonia, cough.

Specific guidance

Not bronhospazm dosage.

Dosing and Administration

Inhalation. Adults up to eight inhalations per day (2 mg); Children 2 inhalation (500 µ g). Flunizolid sprays : primary dose-2 hits in each nostril twice / day (200 g / day). The maximum dose should not exceed eight inhalations in each nostril per day (400 g / day). After reaching effect dose can be reduced. Children 6-14 years : initial dose-1 injection into each nostril three times a day or 2 injection into each nostril twice a day with a total dose of 150-µ g / sut. The maximum dose should not exceed 4 inhalations in each nostril per day (200 g / day).

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