Fluocinolone acetonide

Chemical name

(6альфа,11бета,16альфа)-6, 9-Дифтор-11,21-дигидрокс��-16,17-[(1-метилэтилиден) бис(окси)]-прегна-1,4-ди��н-3,20-дион

Gross

C24-H30-F2-O6

Characteristics

White or white with kremovatam white crystalline powder, practically insoluble in water, soluble in alcohol.

Of drugs

The drugs-glukokortikoidne, antiinflammatory, protiwallergicescoe, protivozudnoe. Associated with specific receptors located in zitoplazme Organs cells and activates Mrnk synthesis; Produces education belkov-lipokortinov-one lipomodulin, oppressing activity fosfolipaza A_2. Affects all types of metabolism. Makes catabolised proteins. Decreases glucose disposal insulinzawisimami tissues is giperglikemia, increase glycogen increases fat breakdown, delaying sodium ions and water, contributes to the development of potassium reduces the absorption of calcium ions is gipocalziemia, induces secretion paratgormona mobilization calcium from the bone. Decreases the number of lymphocytes and Eosinophils is eritrotsitoz (stimulates a eritropoetinov). Противовоспалительно е Effects of oppression activity fosfolipaza A_2 and stabilization of cell membranes and organell, incl. lizosom; hinders education arahidonova acid and products metabolism (GHG Тх, lakotriena) ingibiruet gialuronidazu; oppressing division fat cells prevents their degranulation, liberatiou reducing inflammation mediators ( 24596 histamine, serotonin, bradikinin), suppresses the synthesis factor activate platelets. Impact proliferatiou connective tissue. Immunodepressivny and protiwallergiceski effects are a consequence of reducing the amount of migration and B-lymphocytes and the violation of their interaction. Increases protivosokovi effect AD (increases catecholamine levels in the blood), restores sensitivity to adrenoretseptorov norarenalino and adrenalino, big receptacles activate liver enzymes involved in the metabolism of xenobiotics (antitoxic effect). After suction from the surface of the skin associated with a plasma protein, is biotransformation in the liver with the formation of active metabolites. Excreted mainly kidneys.

Indications

Allergic dermatitis, inflammatory diseases of the skin.

Contraindications

Hypersensitivity, breast-feeding (at the end of treatment), children's age (up to 2 years).

Side-Effects

Insomnia, anxiety, arterial hypertension, liver diseases, heart arrhythmia, swelling, muscle weakness, muscle atrophy, osteoporosis, spontaneous fractures, societies ulcer stomach, intestines atony, the propensity to tromboobrazovaniu, napochechnikovaya failure, the secondary immunodeficiency (exacerbation of chronic infectious diseases, infectious generalization process, the development of opportunistic infections), slowing sh processes steroidnyi diabetes, syndrome Itsenko - Kushinga, stunted growth in children, skin atrophy at the site application, gipertrihoz, nurturing, folliculitis, mazeration or dry skin, allergic reactions.

Patient interaction

Reduces activity gipotenziveh, dioreticakih, gipoglikemicakih, anabolic, protiwaritmicakih of drugs potassium. Mochegonne drugs (except kalisberegath) increase the risk of developing gipokaliemii.

Overdosing

There is a skin irritation on the ground of (itching, burning), giperglikemiei, glukozuriei is moving syndrome Itsenko - Kushinga.lechenie : symptomatic of a gradual abolition of the preparation.

Precautions

Are only short courses on small patches of skin. During treatment to be free clothing.

Dosing and Administration

External. Caused to the affected areas of skin 2-4 times a day.

Directory → Hormones and their antagonists → Adrenal → Glukokortikoida → Fluocinolone acetonide